ArticleThe Journal of physiology1995
Characteristic features of inhibitory junction potentials evoked by single stimuli in the guinea-pig isolated taenia caeci.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Neurotransmitters responsible for purinergic motor neurotransmission and regulation of GI motility.Autonomic neuroscience : basic & clinical · 2021Article
- Burnstock and the legacy of the inhibitory junction potential and P2Y1 receptors.Purinergic signalling · 2021Review
- Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- Differential release of β-NAD(+) and ATP upon activation of enteric motor neurons in primate and murine colons.Neurogastroenterology and motility · 2013Article
- Purinergic mechanisms in the control of gastrointestinal motility.Purinergic signalling · 2008Article
- Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Excitatory purinergic neurotransmission in smooth muscle of guinea-pig [corrected] taenia caeci.The Journal of physiology · 2005Article
- Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum.The Journal of physiology · 2003Article
- Neuroeffector transmission to different layers of smooth muscle in the rat penile bulb.The Journal of physiology · 2000Article
- Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.British journal of pharmacology · 1999Article
- Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO.British journal of pharmacology · 1999Article
- Apamin- and nitric oxide-sensitive biphasic non-adrenergic non-cholinergic inhibitory junction potentials in the rat anococcygeus muscle.The Journal of physiology · 1998Article
- Hypoxia-induced inhibition of calcium channels in guinea-pig taenia caeci smooth muscle cells.The Journal of physiology · 1997Article
- Electric field stimulation-induced guinea pig gallbladder contractions: role of calcium channels in acetylcholine release.Digestive diseases and sciences · 1997Article
- The possible role of ATP and PACAP as mediators of apaminsensitive NANC inhibitory junction potentials in circular muscle of guinea-pig colon.British journal of pharmacology · 1996Article
- Hyperpolarization and inhibition of contraction mediated by nitric oxide released from enteric inhibitory neurones in guinea-pig taenia coli.British journal of pharmacology · 1996Article
- Properties of the inhibitory junction potential in smooth muscle of the guinea-pig gastric fundus.British journal of pharmacology · 1996Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. Changes in membrane potential of the guinea-pig isolated taenia caeci evoked by single stimuli have been investigated using intracellular recording techniques. Nifedipine (10 microM) was used to arrest spontaneous muscle action potentials. Single stimuli elicited complex junction potentials which consisted of both excitatory and inhibitory components. 2. The excitatory component of the compound junction potential was unaffected by hexamethonium (100 microM) but abolished by atropine (1 microM) and omega-conotoxin GVIA (10-100 nM). 3. In the presence of atropine, single stimuli elicited fast inhibitory junction potentials (IJPs). IJPs were sometimes biphasic during repolarization with a noticeable 'slow tail'. Apamin (30-100 nM) potently inhibited the fast IJP and revealed an underlying slow IJP. 4. The fast IJP was also abolished by omega-conotoxin GVIA (100 nM). However, the slow IJP was insensitive to omega-conotoxin GVIA but was abolished by cadmium (30 microM). 5. Guanethidine (3 microM) and N omega-nitro-L-arginine (10-100 microM) had no detectable effects on either of the IJPs. The dye Reactive Blue 2 reduced the amplitude of the fast IJP but this reduction was associated with a membrane hyperpolarization. 6. The existence of two distinct IJPs in the guinea-pig taenia caeci has been demonstrated. The ability of omega-conotoxin GVIA to selectively abolish the fast IJP leaving the slow IJP intact suggests that separate nerves are involved in mediating these responses.
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