ArticleThe Journal of clinical investigation1995
Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 104 citations in OpenAlex.
- T cells in cardiovascular disease: solved and unsolved mysteries.Science China. Life sciences · 2026Review
- Propolis Reduces Inflammation and Dyslipidemia Caused by High-Cholesterol Diet in Mice by Lowering ADAM10/17 Activities.Nutrients · 2024Article
- The effect of hyperlipidemia on bone graft regeneration of peri-implantal created defects in rabbits.International journal of implant dentistry · 2019Article
- Immunosuppression Agent Cyclosporine Reduces Self-Renewal and Vessel Regeneration Potentiation of Human Endothelial Colony Forming Cells.Stem cells translational medicine · 2019Article
- Inhibition of extracellular cyclophilins with cyclosporine analog and development of atherosclerosis in apolipoprotein E-deficient mice.The Journal of pharmacology and experimental therapeutics · 2015Article
- The effect of interferon γ on endothelial cell nitric oxide production and apoptosis.Advanced biomedical research · 2012Article
- Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation.Journal of the American College of Cardiology · 2011Article
- Effects of immunomodulatory drugs on plasma inflammatory markers in a rabbit model of atherosclerosis.Journal of physiology and biochemistry · 2011Article
- Attenuated combined action of cyclosporine a and hyperlipidemia on atherogenesis in rabbits by thymoquinone.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Oxidative stress in children on hemodialysis: value of autoantibodies against oxidized low-density lipoprotein.Pediatric nephrology (Berlin, Germany) · 2009Article
- Immunization for atherosclerosis.Current atherosclerosis reports · 2007Review
- Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- mice.The American journal of pathology · 2000Article
- Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.Molecular medicine (Cambridge, Mass.) · 1999Article
- Mildly oxidized low-density lipoproteins decrease early production of interleukin 2 and nuclear factor kappaB binding to DNA in activated T-lymphocytes.The Biochemical journal · 1999Article
- Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.The Journal of clinical investigation · 1998Article
- Mildly oxidized low-density lipoproteins suppress the proliferation of activated CD4+ T-lymphocytes and their interleukin 2 receptor expression in vitro.The Biochemical journal · 1998Article
- The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.The Journal of clinical investigation · 1997Article
- T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity.The Journal of clinical investigation · 1997Article
- Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice.The American journal of pathology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes are present in atherosclerotic lesions, but the role of this cell type in the disease process has not been determined. To determine whether cell-mediated immunity influences atherogenesis, New Zealand White rabbits fed a cholesterol-supplemented diet (0.5% wt/wt) were treated with cyclosporin A (n = 20) or vehicle alone (n = 16) for 12 wk. The dose of cyclosporin A was adjusted so that a blood concentration between 100 and 200 ng/ml was maintained to achieve a selective action T-lymphocytes. Effectiveness of immunosuppression in cyclosporin A-treated rabbits was confirmed by allogeneic skin graft survival. Cyclosporin A administration did not affect total plasma lipid concentrations, body weight, or renal function. Percentage of aortic intimal area covered with atherosclerotic lesions was increased significantly by immunosuppression in both the arch region (75 +/- 3% [mean +/- SEM] compared with 60 +/- 5% in controls; P < 0.01) and the thoracic region (47 +/- 7% vs 27 +/- 6%; P = 0.04). Enhanced atherogenesis was not associated with diminished numbers of T lymphocytes in lesions, changes in T lymphocyte subtype, or any discernible change in cellular composition. Humoral immune responses to oxidized LDL were similar in the two groups: serum titres of autoantibodies against malondialdehyde-modified LDL were equivalent. These data demonstrate that cyclosporin A-induced suppression of cell-mediated immunity increased the development of macrophage-rich atherosclerotic lesions in cholesterol-fed rabbits.
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