ArticleThe Journal of clinical investigation1995
Coexistence of C/EBP alpha, beta, growth-induced proteins and DNA synthesis in hepatocytes during liver regeneration. Implications for maintenance of the differentiated state during liver growth.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
- Multi-Omics Feature Selection to Identify Biomarkers for Hepatocellular Carcinoma.Metabolites · 2025Article
- Three Dimensional Bioprinting for Hepatic Tissue Engineering: From In Vitro Models to Clinical Applications.Tissue engineering and regenerative medicine · 2024Review
- Chemokine production induced by Corynebacterium pseudotuberculosis in a murine model.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Global properties of regulatory sequences are predicted by transcription factor recognition mechanisms.Genome biology · 2021Article
- Direct conversion of porcine primary fibroblasts into hepatocyte-like cells.Scientific reports · 2021Article
- Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver.Genome research · 2021Article
- Liver regeneration: biological and pathological mechanisms and implications.Nature reviews. Gastroenterology & hepatology · 2021Review
- Functional compensation precedes recovery of tissue mass following acute liver injury.Nature communications · 2020Article
- Graft Regeneration and Functional Recovery in Patients with Early Allograft Dysfunction After Living-Donor Liver Transplantation.Annals of transplantation · 2018Article
- Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration.Physiological genomics · 2017Article
- A cellular, molecular, and pharmacological basis for appendage regeneration in mice.Genes & development · 2015Article
- Regulation of hepatocyte identity and quiescence.Cellular and molecular life sciences : CMLS · 2015Review
- Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte.Liver international : official journal of the International Association for the Study of the Liver · 2015Review
- Chemokine-mediated robust augmentation of liver engraftment: a novel approach.Stem cells translational medicine · 2015Article
- Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.Cell stem cell · 2014Article
- Temporal mapping of CEBPA and CEBPB binding during liver regeneration reveals dynamic occupancy and specific regulatory codes for homeostatic and cell cycle gene batteries.Genome research · 2013Article
- Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration.Hepatology (Baltimore, Md.) · 2011Article
- Cascades of transcription regulation during liver regeneration.The international journal of biochemistry & cell biology · 2011Review
- Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice.Hepatology (Baltimore, Md.) · 2010Article
- RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats.The American journal of pathology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During the period of rapid cell growth which follows a two-thirds partial hepatectomy, the liver is able to compensate for the acute loss of two-thirds of its mass to maintain serum glucose levels and many of its differentiation-specific functions. However certain hepatic transcription factors, C/EBP alpha and beta, which are important for establishment and maintenance of the differentiated state, have been shown to be antagonistic to cellular proliferation. To study the interplay between differentiation and cell growth in the liver regeneration model of hepatocyte proliferation, we characterized the expression of C/EBP alpha and beta transcription factors throughout the temporal course of liver regeneration. As determined by immunoblot, the level of C/EBP alpha decreases more than twofold during the mid to late G1 and S phase (8-24 h after hepatectomy) coordinately with a threefold increase in expression of C/EBP beta. Renormalization of the levels of these proteins occurs after the major proliferative phase. This inverse regulation of C/EBP alpha and beta results in up to a sevenfold increase in the beta / alpha DNA binding ratio between 3 and 24 h after hepatectomy that may have an important impact on target gene regulation. However, total C/EBP binding activity in nuclear extracts remains relatively constant during the 7-d period after hepatectomy. By immunohistochemistry, both C/EBP alpha and beta are expressed in virtually all hepatocyte nuclei throughout the liver during the temporal course of liver regeneration, and there is no exclusion of expression from hepatocytes that are expressing immediate-early gene products or undergoing DNA synthesis. The persistent expression of C/EBP alpha and beta isoforms predicts that C/EBP proteins contribute to the function of hepatocytes during physiologic growth and that significant amounts of these proteins do not inhibit progression of hepatocytes into S phase of the cell cycle.
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