Evidence map›Paper›PMID 7657802›Full record

ArticleThe Journal of clinical investigation1995

Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.

O Nakagawa, Y Ogawa, H Itoh, S Suga, Y Komatsu, I Kishimoto, K Nishino, T Yoshimasa, K Nakao

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00521976 (An Investigation of Activated Factor XII), which is not on this map. Cited by 122 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00521976 completednot on this mapstarted 2002, after this paper: background citation

An Investigation of Activated Factor XII (Fxlla) as a Prognostic Marker.

TypeobservationalSponsorHelse Stavanger HFRan2002 to 2005Enrolled871ConditionsChest Pain, Coronary Artery Disease, Unstable Angina Pectoris, Myocardial Infarction
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 2 syntheses or guidelines pooled it, 624 citations in OpenAlex.

  1. Pooled it
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  3. Trial
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  7. Review
  8. Article
  9. Article
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  11. Biomarkers in Heart Failure: A Review and a Wish.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Blunted increase in plasma BNP during acute coronary syndrome attacks in obese patients.International journal of cardiology. Heart & vasculature · 2024
    Article
  18. Review
  19. Article
  20. Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

O NakagawaDepartment of Medicine, Kyoto University Faculty of Medicine, Japan.
Y Ogawa
H Itoh
S Suga
Y Komatsu
I Kishimoto
K Nishino
T Yoshimasa
K Nakao
Kyoto University · JPKyoto University of Education · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone mainly produced in the ventricle, while the major production site of atrial natriuretic peptide (ANP) is the atrium. To assess the pathophysiological role of BNP in ventricular overload, we have examined the gene expression of BNP, In comparison with that of ANP, in a model of cardiac hypertrophy using cultured neonatal rat ventricular cardiocytes. During cardiocyte hypertrophy evoked by endothelin-1, Phenylephrine, or PMA, the steady state level of BNP mRNA increased as rapidly as the "immediate-early" induction of the c-fos gene expression, and reached a maximal level within 1 h. Actinomycin D, a transcriptional inhibitor, completely diminished the response, while the translational blocked with cycloheximide did not inhibit it. In contrast, ANP mRNA began to increase 3 h after the stimulation, and accumulated during cardiocyte hypertrophy. The BNP secretion from ventricular cardiocytes was also stimulated, more rapidly than the ANP secretion. Furthermore, the turnover of BNP mRNA was significantly faster than that of ANP mRNA, being consistent with the existence of AUUUA motif in the 3'-untranslated region of BNP mRNA. These results demonstrate that the gene expression of BNP is distinctly regulated from that of ANP at transcriptional and posttranscriptional levels, and indicate that the characteristics of the BNP gene expression are suitable for its possible role as an " emergency" cardiac hormone against ventricular overload.

Indexed as

Gene Expression RegulationTranscription, GeneticAnimalsAnimals, NewbornAtrial Natriuretic FactorBase SequenceCardiomegalyCells, CulturedChromatography, GelChromatography, High Pressure LiquidDNA PrimersEndothelinsEnzyme ActivationHeart VentriclesKineticsMolecular Sequence DataAtrial Natriuretic FactorDNA PrimersEndothelinsNatriuretic Peptide, BrainNerve Tissue ProteinsPhenylephrineProtein Kinase CRNA, MessengerTetradecanoylphorbol Acetate

Identifiers

PMID7657802
PMCPMC185749
OpenAlexW2046971992

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.