ArticleThe Journal of clinical investigation1995
Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 137 citations in OpenAlex.
- Article
- Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors.Cellular and molecular life sciences : CMLS · 2016Review
- Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses.Frontiers in microbiology · 2016Review
- The Pathogenesis of Human Cervical Epithelium Cells Induced by Interacting with Trichomonas vaginalis.PloS one · 2015Article
- The macrophage migration inhibitory factor homolog of Entamoeba histolytica binds to and immunomodulates host macrophages.Infection and immunity · 2014Article
- Function and expression of cystic fibrosis transmembrane conductance regulator after small intestinal transplantation in mice.PloS one · 2013Article
- The dynamic interdependence of amebiasis, innate immunity, and undernutrition.Seminars in immunopathology · 2012Review
- Lactobacillus acidophilus induces cytokine and chemokine production via NF-κB and p38 mitogen-activated protein kinase signaling pathways in intestinal epithelial cells.Clinical and vaccine immunology : CVI · 2012Article
- Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing.Infection and immunity · 2012Article
- Fusobacterium nucleatum and human beta-defensins modulate the release of antimicrobial chemokine CCL20/macrophage inflammatory protein 3α.Infection and immunity · 2011Article
- Tissue destruction and invasion by Entamoeba histolytica.Trends in parasitology · 2011Review
- An ex-vivo human intestinal model to study Entamoeba histolytica pathogenesis.PLoS neglected tropical diseases · 2009Article
- Prostaglandin E2 produced by Entamoeba histolytica binds to EP4 receptors and stimulates interleukin-8 production in human colonic cells.Infection and immunity · 2008Article
- Differential induction of immunoregulatory circuits of phagocytic cells by Gal/Gal NAc lectin from pathogenic and nonpathogenic Entamoeba.Journal of clinical immunology · 2008Article
- Blastocystis ratti contains cysteine proteases that mediate interleukin-8 response from human intestinal epithelial cells in an NF-kappaB-dependent manner.Eukaryotic cell · 2008Article
- Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.Current opinion in immunology · 2007Review
- Induction of monocyte chemotactic protein 1 in colonic epithelial cells by Entamoeba histolytica is mediated via the phosphatidylinositol 3-kinase/p65 pathway.Infection and immunity · 2007Article
- Intestinal mucosal responses to microbial infection.Springer seminars in immunopathology · 2005Review
- Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors.Infection and immunity · 2004Article
- Expression of amoebapores is required for full expression of Entamoeba histolytica virulence in amebic liver abscess but is not necessary for the induction of inflammation or tissue damage in amebic colitis.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and cause extensive lysis of host cells. The acute amebic lesions in animal models are characterized by infiltration with inflammatory cells, particularly neutrophils. The acute host response is likely important for determining whether the infection will spread systemically, but little is known regarding the signals which initiate an acute inflammatory response to E. histolytica. In the studies reported herein, we used an in vitro model system to define the proinflammatory signals produced by epithelial and other host cells in response to infection with E. histolytica trophozoites. Coculture of human epithelial and stromal cells and cell lines with trophozoites is shown to increase expression and secretion of an array of chemoattractant and proinflammatory cytokines, including IL-8, GRO alpha, GM-CSF, IL-1 alpha, and IL-6. Moreover, high-level secretion of those cytokines is regulated by the paracrine action of cytolytically released IL-1 alpha. A second mechanism for trophozoite-induced IL-8 production involves trophozoite-target cell contact via a galactose-inhibitable amebic adherence protein, and appears to be mediated through increased intracellular calcium levels. These studies define novel mechanisms through which acute inflammation can be initiated in the host in response to a cytolytic pathogen, such as E. histolytica.
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