ArticleThe Journal of cell biology1995
Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 190 citations in OpenAlex.
- CaScience advances · 2025Article
- Synaptic tau: A pathological or physiological phenomenon?Acta neuropathologica communications · 2021Review
- The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells.Nature communications · 2016Article
- Intracellular Ca2+ signaling and preimplantation development.Advances in experimental medicine and biology · 2015Review
- Proteomic analysis of the presynaptic active zone.Experimental brain research · 2012Review
- Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome.Molecular & cellular proteomics : MCP · 2012Article
- Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin.The Journal of biological chemistry · 2010Article
- Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Identification of a functional splice variant of 14-3-3E1 in rainbow trout.Marine biotechnology (New York, N.Y.) · 2010Article
- Interaction with calmodulin is important for the secretion of thimet oligopeptidase following stimulation.The FEBS journal · 2009Article
- Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Blastocysts don't go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells.Developmental biology · 2005Review
- Structural domains involved in the regulation of transmitter release by synapsins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles.Pflugers Archiv : European journal of physiology · 2004Review
- Ca2+/calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.Molecular biology of the cell · 2003Article
- Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta.The Biochemical journal · 2003Article
- Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells.Molecular biology of the cell · 2002Article
- Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.The EMBO journal · 2002Article
- Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have used stage-specific assays for MgATP-dependent priming and for Ca(2+)-activated triggering in the absence of free MgATP to examine the effects of alpha-SNAP, 14-3-3 proteins and calmodulin on regulated exocytosis in permeabilized adrenal chromaffin cells. All three proteins lead to a Ca(2+)-dependent increase in catecholamine secretion. Both alpha-SNAP and 14-3-3 proteins stimulated in a priming but not in a triggering assay. In contrast, calmodulin was stimulatory in triggering but not priming. The effects of alpha-SNAP and 14-3-3 proteins were likely to be due to distinct mechanisms of action since they differed in Ca(2+)-dependency, time course and extent of stimulation and their effects were additive. alpha-SNAP and 14-3-3 proteins did not appear to exert their priming action through changes in synthesis of phosphatidylinositol (4,5) bisphosphate. The data show that these three proteins have distinct stage-specific actions on exocytosis and indicate that alpha-SNAP acts in an early MgATP-requiring stage and not in the late Ca(2+)-triggered steps immediately prior to membrane fusion as previously suggested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.