ArticleThe Journal of cell biology1995
A role for tubular networks and a COP I-independent pathway in the mitotic fragmentation of Golgi stacks in a cell-free system.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The function of GORASPs in Golgi apparatus organization in vivo.The Journal of cell biology · 2020Article
- Golgi biogenesis.Cold Spring Harbor perspectives in biology · 2011Review
- Golgi inheritance in mammalian cells is mediated through endoplasmic reticulum export activities.Molecular biology of the cell · 2006Article
- A direct role for GRASP65 as a mitotically regulated Golgi stacking factor.The EMBO journal · 2003Article
- Golgi clusters and vesicles mediate mitotic inheritance independently of the endoplasmic reticulum.The Journal of cell biology · 2001Article
- The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus.The Journal of cell biology · 2001Article
- Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis.Molecular biology of the cell · 2000Article
- The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130.The Journal of cell biology · 2000Article
- MEK and Cdc2 kinase are sequentially required for Golgi disassembly in MDCK cells by the mitotic Xenopus extracts.The Journal of cell biology · 2000Article
- A role for the vesicle tethering protein, p115, in the post-mitotic stacking of reassembling Golgi cisternae in a cell-free system.The Journal of cell biology · 1999Article
- The Golgi and endoplasmic reticulum remain independent during mitosis in HeLa cells.Molecular biology of the cell · 1998Article
- Role of NAD+ and ADP-ribosylation in the maintenance of the Golgi structure.The Journal of cell biology · 1997Article
- Partitioning of the Golgi apparatus during mitosis in living HeLa cells.The Journal of cell biology · 1997Article
- Dissociation of coatomer from membranes is required for brefeldin A-induced transfer of Golgi enzymes to the endoplasmic reticulum.The Journal of cell biology · 1997Article
- Sorting by COP I-coated vesicles under interphase and mitotic conditions.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Golgi stacks were previously shown to be converted into tubular networks when incubated in mitotic cytosol depleted of the coatomer subunit of COP I coats (Misteli and Warren, 1994). Similar, though smaller, networks are now shown to be an early intermediate on the Golgi fragmentation pathway both in vitro and in vivo. Their appearance mirrors the disappearance of Golgi cisternae and at their peak they constitute 35% of total Golgi membrane. They are consumed by two pathways, the first involving the budding of COP I-coated vesicles described previously (Misteli and Warren, 1994). The second involves a COP I-independent mechanism that leads eventually to a vesicle fraction that is larger in size and more heterogeneous than that produced by the COP I-mechanism. We suggest that both pathways operate concurrently at the onset of mitotic fragmentation. The COP I-independent pathway converts cisternae into tubular networks that then fragment. The COP I-dependent pathway partially consumes first the cisternae at the beginning of the incubation and then the tubular networks that form from them.
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