ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]1995
Association between degree of bone-erosion and synovial fluid-levels of tumor necrosis factor alpha in the knee-joints of patients with rheumatoid arthritis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 88 citations in OpenAlex.
- Bromelain Extract Exerts Antiarthritic Effects via Chondroprotection and the Suppression of TNF-α-Induced NF-κB and MAPK Signaling.Plants (Basel, Switzerland) · 2021Article
- Article
- Cytokine-mediated bone destruction in rheumatoid arthritis.Journal of immunology research · 2014Review
- Stevens-Johnson syndrome complicating adalimumab therapy in rheumatoid arthritis disease.Rheumatology international · 2013Article
- Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee.BMC musculoskeletal disorders · 2011Article
- Review
- Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane.Rheumatology international · 2006Article
- Use of digital x ray radiogrammetry in the assessment of joint damage in rheumatoid arthritis.Annals of the rheumatic diseases · 2006Article
- Tumor necrosis factor-alpha in temporomandibular joint synovial fluid predicts treatment effects on pain by intra-articular glucocorticoid treatment.Mediators of inflammation · 2006Article
- Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis.Annals of the rheumatic diseases · 2000Review
- Increased synovial fluid levels of soluble CD23 are associated with an erosive status in rheumatoid arthritis (RA).Clinical and experimental immunology · 2000Article
- Macrophages in rheumatoid arthritis.Arthritis research · 2000Review
- Etanercept: therapeutic use in patients with rheumatoid arthritis.Annals of the rheumatic diseases · 1999Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether concentrations of cytokines and matrix-degrading enzymes in synovial fluid of patients with rheumatoid arthritis or osteoarthritis are associated with the degree of bone-destruction in the same joint.
methodsDetermination of Interleukin-1 alpha, IL-1 beta, IL-1-receptor-antagonist, IL-6, IL-8, tumor necrosis factor alpha (by ELISA), collagenase-activity and caseinase-activity (by substrate-assays) in the SF (knee) of patients with RA (n42) or OA (n35). The degree of bone-destruction was assessed radiographically.
resultsSF cytokine- and enzyme-levels were higher in patients with RA than in those with OA. In the RA group, SF-levels of TNF alpha were positively correlated with the degree of bone destruction of the respective joint. No correlation was found between radiographically assessed joint changes and SF-concentrations of other cytokines, enzyme activities, serum CRP, or duration of disease. In the OA-group, none of the examined parameters was associated with the degree of joint destruction.
conclusionsOur data may support the assumption of TNF alpha playing an important role in joint destruction in RA. Possible alternative conclusions are discussed.
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