ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]1995
Modulins: a new class of cytokine-inducing, pro-inflammatory bacterial virulence factor.
Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats.BMC infectious diseases · 2008Article
- Immunotherapy of cancer for the elderly patient: does allogeneic bone marrow transplantation after nonmyeloablative conditioning provide a new option?Cancer immunology, immunotherapy : CII · 2004Review
- Dependence of positive effects of granulocyte colony-stimulating factor on the antibiotic regimen: evaluation in rats with polymicrobial peritonitis.World journal of surgery · 2004Article
- Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients.Infection and immunity · 2001Article
- Specific immunotherapy of cancer in elderly patients.Drugs & aging · 2001Review
- Interleukin-1 inhibits gamma interferon-induced bacteriostasis in human uroepithelial cells.Infection and immunity · 1999Article
- An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization.The Journal of experimental medicine · 1999Article
- Mechanistic bases for adverse vaccine reactions and vaccine failures.Advances in veterinary medicine · 1999Review
- Bacterial perturbation of cytokine networks.Infection and immunity · 1998Review
- Systemic adverse reactions in young Simmental calves following administration of a combination vaccine.The Canadian veterinary journal = La revue veterinaire canadienne · 1997Article
- Bacterially induced bone destruction: mechanisms and misconceptions.Infection and immunity · 1996Review
- Molecular chaperones and disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the fact that the inflammatory and immune responses have evolved to combat microorganisms, the present generation of inflammation researchers has evinced relatively little interest, with the exception of septic shock, in microbially-induced inflammation. This in spite of the fact that the Gram-negative cell wall constituent, lipopolysaccharide, has been widely used as a tool in inflammation research. The reason for such lack of interest has been due to the therapeutic efficacy of antibiotics which are the treatment of choice for infections and their inflammatory sequelae. However, this is likely to change within the next decade or so, with the relentless increase in the incidence of antibiotic-resistant strains of bacteria. This will return therapy to the stage where clinicians will have to treat the inflammatory symptoms of infection. Many of these symptoms are due to the stimulation of cytokine synthesis. The capacity of bacteria to induce cytokine synthesis has, until the past few years, centred exclusively on lipopolysaccharide. However, it has been established during the past 5-10 years that a range of other molecules, mainly associated with the surface of bacteria, have the capacity to induce cytokine production. Some of these are exquisitely potent stimulators of pro-inflammatory cytokine synthesis. The nature and mechanism of action of these various cytokine-inducing molecules, for which we have devised the name modulins, is the subject of this review. It is clear that bacteria still have many surprises for us, as exemplified by the recent discovery of the role played by Helicobacter pylori in gastritis, gastric ulceration and gastric cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.