ArticleThe Biochemical journal1995
Parathyroid hormone induces protein kinase C but not adenylate cyclase in adult cardiomyocytes and regulates cyclic AMP levels via protein kinase C-dependent phosphodiesterase activity.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 84 citations in OpenAlex.
- Evaluation of left ventricular functions in patients with primary hyperparathyroidism: is there any effect of parathyroidectomy?Wiener klinische Wochenschrift · 2017Trial
- Elabela increases in patients with primary hyperparathyroidism, especially in the presence of surgery indication.BMC endocrine disorders · 2025Article
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- The Molecular Mechanisms Underlying the Systemic Effects Mediated by Parathormone in the Context of Chronic Kidney Disease.Current issues in molecular biology · 2024Review
- Left anterior descending artery disease in a 27-year-old with multiple endocrine neoplasia, type 2A: A case report.SAGE open medical case reports · 2023Article
- Antiosteoporosis medications and cardiovascular disease: a population-based nationwide nested case-control study.Frontiers in pharmacology · 2023Article
- The Interplay Between the Renin-Angiotensin-Aldosterone System and Parathyroid Hormone.Frontiers in endocrinology · 2020Review
- Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice.American journal of physiology. Heart and circulatory physiology · 2018Article
- Plasma parathyroid hormone and cardiovascular disease in treatment-naive patients with primary hyperparathyroidism: The EPATH trial.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population.Mayo Clinic proceedings · 2017Article
- PTH and Vitamin D.Comprehensive Physiology · 2016Review
- Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation.Biochemical and biophysical research communications · 2015Article
- Evaluation of left ventricle functions by tissue Doppler, strain, and strain rate echocardiography in patients with primary hyperparathyroidism.Endocrine · 2014Article
- Cardiac structure and functions in patients with asymptomatic primary hyperparathyroidism.Journal of endocrinological investigation · 2013Article
- Can parathyroid hormone be used as a biomarker for heart failure?Heart failure reviews · 2013Review
- A Novel Approach for High Level Expression of Soluble Recombinant Human Parathyroid Hormone (rhPTH 1-34) in Escherichia coli.Avicenna journal of medical biotechnology · 2013Article
- Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.The Journal of biological chemistry · 2010Article
- Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Normocalcemia and persistent elevated serum concentrations of 1-84 parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of increased morbidity from cardiovascular disease.World journal of surgery · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult ventricular cardiomyocytes have been identified as target cells for parathyroid hormone (PTH) but little is known about its signal transduction in these cells. In the present study the influence of PTH on cyclic AMP accumulation and the activity of protein kinase C (PKC) in cardiomyocytes was evaluated. A mid-regional synthetic fragment of PTH, PTH-(28-48), which exerts a hypertrophic effect on cardiomyocytes, increased the activity of membrane-associated PKC in a dose-dependent manner (1-100 nM). Activated membranous PKC was dependent on Ca2+ and sensitive to an inhibitor of Ca(2+)-dependent isoforms of PKC. When adenylate cyclase was stimulated by the addition of isoprenaline, a beta-adrenoceptor agonist, PTH-(28-48) antagonized cyclic AMP accumulation. This antagonistic effect of PTH-(28-48) could be mimicked by activation of PKC with a phorbol ester and inhibited by isobutylmethylxanthine, a phosphodiesterase inhibitor. An N-terminal synthetic fragment, PTH-(1-34), which includes an adenylate cyclase-activating domain, did not stimulate the accumulation of cyclic AMP in cardiomyocytes. The results demonstrate that in adult cardiomyocytes PTH (1) is able to stimulate PKC, (2) is not able to cause accumulation of cyclic AMP and (3) functionally antagonizes the effect of beta-adrenoceptor stimulation to increase cellular cyclic AMP concentrations via PKC-dependent phosphodiesterase activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.