ArticleMolecular and cellular biology1995
A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 112 citations in OpenAlex.
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Redox regulation of memory formation by Rrp1 inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-faceted regulation of CREB family transcription factors.Frontiers in molecular neuroscience · 2024Review
- M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development.Nature communications · 2023Article
- Memory phase-specific genes in the Mushroom Bodies identified using CrebB-target DamID.PLoS genetics · 2023Article
- CREBB repression of protein synthesis in mushroom body gates long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- CREBA and CREBB in two identified neurons gate long-term memory formation inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium.Cell reports · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.Current biology : CB · 2019Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.eLife · 2018Article
- Genome-wide DNA methylation changes associated with olfactory learning and memory in Apis mellifera.Scientific reports · 2017Article
- Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.Nature communications · 2016Article
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Human molecular genetics · 2016Article
- From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment.Frontiers in psychiatry · 2015Review
- Time of day influences memory formation and dCREB2 proteins in Drosophila.Frontiers in systems neuroscience · 2014Article
- Nuclear gating of a Drosophila dCREB2 activator is involved in memory formation.Neurobiology of learning and memory · 2013Article
- dCREB2-mediated enhancement of memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have characterized a Drosophila gene that is a highly conserved homolog of the mammalian cyclic AMP (cAMP)-responsive transcription factors CREB and CREM. Uniquely among Drosophila genes characterized to date, it codes for a cAMP-responsive transcriptional activator. An alternatively spliced product of the same gene is a specific antagonist of cAMP-inducible transcription. Analysis of the splicing pattern of the gene suggests that the gene may be the predecessor of the mammalian CREB and CREM genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.