ArticleMolecular and cellular biology1995
Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Pathway network inference from gene expression data.BMC systems biology · 2014Article
- Pseudohyphal regulation by the transcription factor Rfg1p in Candida albicans.Eukaryotic cell · 2010Article
- Cyclin regulation by the s phase checkpoint.The Journal of biological chemistry · 2010Article
- Mitotic Cdc6 stabilizes anaphase-promoting complex substrates by a partially Cdc28-independent mechanism, and this stabilization is suppressed by deletion of Cdc55.Molecular and cellular biology · 2007Article
- Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Molecular and cellular biology · 2006Article
- The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.The EMBO journal · 2005Article
- The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.Molecular and cellular biology · 2005Article
- Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.Molecular and cellular biology · 2004Article
- Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.Molecular biology of the cell · 2003Article
- Article
- Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1998Review
- Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae.The Journal of cell biology · 1998Article
- Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells.Molecular biology of the cell · 1998Article
- Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities.Molecular and cellular biology · 1996Article
- Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases.Molecular biology of the cell · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell cycle progression in the budding yeast Saccharomyces cerevisiae is controlled by the Cdc28 protein kinase, which is sequentially activated by different sets of cyclins. Previous genetic analysis has revealed that two B-type cyclins, Clb5 and Clb6, have a positive role in DNA replication. In the present study, we show, in addition, that these cyclins negatively regulate G1- and G2-specific functions. The consequences of this negative regulation were most apparent in clb6 mutants, which had a shorter pre-Start G1 phase as well as a shorter G2 phase than congenic wild-type cells. As a consequence, clb6 mutants grew and proliferated more rapidly than wild-type cells. It was more difficult to assess the role of Clb5 in G1 and G2 by genetic analysis because of the extreme prolongation of S phase in clb5 mutants. Nevertheless, both Clb5 and Clb6 were shown to be responsible for down-regulation of the protein kinase activities associated with Cln2, a G1 cyclin, and Clb2, a mitotic cyclin, in vivo. These observations are consistent with the observed cell cycle phase accelerations associated with the clb6 mutant and are suggestive of similar functions for Clb5. Genetic evidence suggested that the inhibition of mitotic cyclin-dependent kinase activities was dependent on and possibly mediated through the CDC6 gene product. Thus, Clb5 and Clb6 may stabilize S phase by promoting DNA replication while inhibiting other cell cycle activities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.