ArticleMolecular and cellular biology1995
Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 90 citations in OpenAlex.
- Contrasting mutation patterns in haploid and diploid cells from two yeast species.bioRxiv : the preprint server for biology · 2025Article
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- Genetic Regulation of Mitosis-Meiosis Fate Decision in Plants: Is Callose an Oversighted Polysaccharide in These Processes?Plants (Basel, Switzerland) · 2023Review
- Pheromone Response and Mating Behavior in Fission Yeast.Microbiology and molecular biology reviews : MMBR · 2022Review
- Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance.PLoS biology · 2021Article
- Gamete fusion triggers bipartite transcription factor assembly to block re-fertilization.Nature · 2018Article
- Functional and Expression Analyses of themBio · 2018Article
- Long noncoding RNA-based chromatin control of germ cell differentiation: a yeast perspective.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Reduction of ribosome level triggers flocculation of fission yeast cells.Eukaryotic cell · 2013Article
- Proper microtubule structure is vital for timely progression through meiosis in fission yeast.PloS one · 2013Article
- Article
- Regulation of entry into gametogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe.Molecular systems biology · 2011Article
- A novel class of peptide pheromone precursors in ascomycetous fungi.Molecular microbiology · 2010Article
- The selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Article
- Schizosaccharomyces pombe switches mating type by the synthesis-dependent strand-annealing mechanism.Genetics · 2007Article
- Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties.Protein science : a publication of the Protein Society · 2007Article
- Molecular mechanisms underlying the mitosis-meiosis decision.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mat1 locus is a key regulator of both conjugation and meiosis in the fission yeast Schizosaccharomyces pombe. Two alternative DNA segments of this locus, mat1-P and mat1-M, specify the haploid cell types (Plus and Minus). Each segment includes two genes: mat1-P includes mat1-Pc and mat1-Pm, while mat1-M includes mat1-Mc and mat1-Mm. The mat1-Pc and mat1-Mc genes are responsible for establishing the pheromone communication system that mediates conjugation between P and M cells, while all four mat1 genes are required for meiosis in diploid P/M cells. Our understanding of the initiation of meiosis is based largely on indirect observations, and a more precise investigation of these events was required to define the interaction between the mat1 genes. Here we resolve this issue using synthetic pheromones and P/M strains with mutations in either mat1-Pc or mat1-Mc. Our results suggest a model in which the mat1 locus plays two roles in controlling meiosis. In the first instance, the mat1-Pc and mat1-Mc functions are required to produce the mating pheromones and receptors that allow the generation of a pheromone signal. This signal is required to induce the expression of mat1-Pm and mat1-Mm. This appears to be the major pheromone-dependent step in controlling meiosis since ectopic expression of these genes allows meiosis in the absence of mat1-Pc and mat1-Mc. The mat1-Pm and mat1-Mm products complete the initiation of meiosis by activating transcription of the mei3 gene.
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