ArticleMolecular and cellular biology1995
ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites.
Article in Molecular and cellular biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 153 citations in OpenAlex.
- Multi-omics data integration for the identification of biomarkers for bull fertility.PloS one · 2024Article
- Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis.Current opinion in cell biology · 2020Review
- Targeting the Eph/Ephrin System as Anti-Inflammatory Strategy in IBD.Frontiers in pharmacology · 2019Article
- Cellular organization and boundary formation in craniofacial development.Genesis (New York, N.Y. : 2000) · 2019Review
- Supt20 is required for development of the axial skeleton.Developmental biology · 2017Article
- Membrane-mediated regulation of vascular identity.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation.Development (Cambridge, England) · 2014Article
- Ephrin-Eph signaling in embryonic tissue separation.Cell adhesion & migration · 2014Review
- Article
- Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Henipavirus receptor usage and tropism.Current topics in microbiology and immunology · 2012Review
- Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.Developmental biology · 2009Article
- Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keel.Developmental biology · 2009Article
- Coordinated action of N-CAM, N-cadherin, EphA4, and ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick.Current topics in developmental biology · 2008Review
- Can tissue surface tension drive somite formation?Developmental biology · 2007Article
- EphB3 receptor and ligand expression in the adult rat brain.Journal of molecular histology · 2006Article
- A new ephrin-A1 isoform (ephrin-A1b) with altered receptor binding properties abrogates the cleavage of ephrin-A1a.The Biochemical journal · 2004Article
- Tyr-298 in ephrinB1 is critical for an interaction with the Grb4 adaptor protein.The Biochemical journal · 2004Article
- Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms.The Journal of clinical investigation · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
The Eph receptors are the largest known family of receptor tyrosine kinases and are notable for distinctive expression patterns in the nervous system and in early vertebrate development. However, all were identified as orphan receptors, and only recently have there been descriptions of a corresponding family of ligands. We describe here a new member of the Eph ligand family, designated ELF-2 (Eph ligand family 2). The cDNA sequence for mouse ELF-2 indicates that it is a transmembrane ligand. It shows closest homology to the other known transmembrane ligand in the family, ELK-L/LERK-2/Cek5-L, with 57% identity in the extracellular domain. There is also striking homology in the cytoplasmic domain, including complete identity of the last 33 amino acids, suggesting intracellular interactions. On cell surfaces, and in a cell-free system, ELF-2 binds to three closely related Eph family receptors, Elk, Cek10 (apparent ortholog of Sek-4 and HEK2), and Cek5 (apparent ortholog of Nuk/Sek-3), all with dissociation constants of approximately 1 nM. In situ hybridization of mouse embryos shows ELF-2 RNA expression in a segmental pattern in the hindbrain region and the segmenting mesoderm. Comparable patterns have been described for Eph family receptors, including Sek-4 and Nuk/Sek-3, suggesting roles for ELF-2 in patterning these regions of the embryo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.