ArticleMolecular & general genetics : MGG1995
Multiple domains mediate heme control of the yeast activator HAP1.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.Free radical biology & medicine · 2011Article
- Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.The Journal of biological chemistry · 2009Article
- The heme activator protein Hap1 represses transcription by a heme-independent mechanism in Saccharomyces cerevisiae.Genetics · 2005Article
- Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1.Molecular and cellular biology · 2003Article
- The Hsp70-Ydj1 molecular chaperone represses the activity of the heme activator protein Hap1 in the absence of heme.Molecular and cellular biology · 2001Article
- A new class of repression modules is critical for heme regulation of the yeast transcriptional activator Hap1.Molecular and cellular biology · 1999Article
- Molecular mechanism governing heme signaling in yeast: a higher-order complex mediates heme regulation of the transcriptional activator HAP1.Molecular and cellular biology · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The activity of the yeast activator HAP1 in vivo requires heme. A heme responsive domain of HAP1 was identified previously. It is adjacent to the DNA-binding domain and appears to block DNA binding in the absence of heme. Here we describe a novel genetic selection which yielded mutants of HAP1 that are independent of heme when assayed for activation. These mutants define a second region of HAP1, close to the activation domain, which also controls its response to heme.
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