ArticleMolecular & general genetics : MGG1995
The cpc-2 gene of Neurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Regulator of G Protein Signaling Proteins Control Growth, Development and Cellulase Production inJournal of fungi (Basel, Switzerland) · 2022Article
- Structure of the translatingProceedings of the National Academy of Sciences of the United States of America · 2021Article
- A WD40 Protein Encoding GeneFrontiers in microbiology · 2020Article
- Comparative transcriptome analysis revealed genes involved in the fruiting body development ofPeerJ · 2020Article
- Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa.PloS one · 2019Article
- Broad Substrate-Specific Phosphorylation Events Are Associated With the Initial Stage of Plant Cell Wall Recognition inFrontiers in microbiology · 2019Article
- Article
- Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.The Journal of biological chemistry · 2013Article
- Cross-species hybridization with Fusarium verticillioides microarrays reveals new insights into Fusarium fujikuroi nitrogen regulation and the role of AreA and NMR.Eukaryotic cell · 2008Article
- Article
- The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p.Current genetics · 2006Article
- A Sordaria macrospora mutant lacking the leu1 gene shows a developmental arrest during fruiting body formation.Molecular genetics and genomics : MGG · 2005Article
- Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development.Molecular and cellular biology · 2000Article
- RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.Molecular and cellular biology · 1998Article
- Article
- Roles of Rack1 Proteins in Fungal Pathogenesis.BioMed research internationalReview
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Authors and funding
7 authors.
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Abstract
Phenotypic and molecular studies of the mutation U142 indicate that the cpc-2+ gene is required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of Neurospora crassa. The cpc-2 gene was cloned by complementation of the cpc-2 mutation in a his-2ts bradytrophic background. Genomic and cDNA sequence analysis indicated a 1636 bp long open reading frame interrupted by four introns. The deduced 316 amino acid polypeptide reveals 70% positional identity over its full length with G-protein beta-subunit-related polypeptides found in humans, rat (RACK1), chicken, tobacco and Chlamydomonas. With the exception of RACK1 the function of these proteins is obscure. All are entirely made up of seven WD-repeats. Expression studies of cpc-2 revealed one abundant transcript in the wild type; in the mutant its level is drastically reduced. In mutant cells transformed with the complementing sequence, the transcript level, enzyme regulation and female fertility are restored. In the wild type the cpc-2 transcript is down-regulated under conditions of amino acid limitation. With cpc-2 a new element involved in general amino acid control has been identified, indicating a function for a WD-repeat protein that belongs to a class that is conserved throughout the evolution of eukaryotes.
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