ArticleThe Journal of experimental medicine1995
Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- SOX4 controls invariant NKT cell differentiation by tuning TCR signaling.The Journal of experimental medicine · 2018Article
- Prostate cancer health disparities: An immuno-biological perspective.Cancer letters · 2018Article
- Antitumor Responses of Invariant Natural Killer T Cells.Journal of immunology research · 2015Review
- Article
- Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4(+) T cells.Clinical and experimental immunology · 2012Article
- Transcriptional control of invariant NKT cell development.Immunological reviews · 2010Article
- Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.Seminars in immunology · 2010Review
- Raising the NKT cell family.Nature immunology · 2010Review
- Intracellular bacterial infection and invariant NKT cells.Yonsei medical journal · 2009Review
- Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The role of NKT cells in tumor immunity.Advances in cancer research · 2008Review
- The Src family tyrosine kinase Fyn regulates natural killer T cell development.The Journal of experimental medicine · 1999Article
- T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).The Journal of experimental medicine · 1998Article
- Association with FcRgamma is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells.The Journal of experimental medicine · 1997Article
- CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis.Infection and immunity · 1997Article
- Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules.The Journal of experimental medicine · 1997Article
- Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.The Journal of experimental medicine · 1996Article
- NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.The Journal of experimental medicine · 1995Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the structure of the T cell antigen receptor (TCR)-CD3 complex and development of NK1.1+ T cells was investigated. The TCR complex of freshly isolated NK1.1+ TCR-alpha/beta+ thymocytes contained CD3 zeta homodimers and CD zeta-FcR gamma heterodimers, whereas that of the majority of NK1.1- T cells did not contain FcR gamma. The function of CD3 zeta and FcR gamma in the development of NK1.1+ T cells was determined by analyzing CD3 zeta- and FcR gamma-deficient mice. The NK1.1+ T cells from wild-type and CD3 zeta-deficient mice had equal levels of CD3 expression. However, the development of NK1.1+ TCR-alpha/beta+ T cells was almost completely disrupted in thymus and spleen in CD3 zeta-deficient mice, whereas no alteration was observed in FcR gamma-deficient mice. In contrast, the number of novel NK1.1+ TCR-gamma/delta+ thymocytes expressing a surface phenotype similar to NK1.1+ TCR-alpha/beta+ thymocytes increased approximately six times in CD3 zeta-deficient mice. These findings establish the distinct roles of the CD3 zeta chain in the development of the following different thymic T cell compartments: NK1.1- TCR+, NK1.1+ TCR-alpha/beta+, and NK1.1+ TCR-gamma/delta+ thymocytes, which cannot be replaced by CD3 eta or FcR gamma chains.
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