ArticleThe Journal of experimental medicine1995
Involvement of p59fynT in interleukin-5 receptor signaling.
Article in The Journal of experimental medicine, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Fyn kinase is required for optimal humoral responses.PloS one · 2013Article
- Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).Molecular immunology · 2011Article
- Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Interleukin-6-induced proliferation of human myeloma cells associated with CD45 molecules.International journal of hematology · 2003Review
- Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.The EMBO journal · 2002Article
- A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.Molecular and cellular biology · 2000Article
- Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.The Journal of experimental medicine · 1998Article
- Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.The Journal of experimental medicine · 1998Article
- The molecular mechanism of B cell activation by toll-like receptor protein RP-105.The Journal of experimental medicine · 1998Article
- Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Control of B cell development by Ras-mediated activation of Raf.The EMBO journal · 1997Article
- Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival.The Journal of experimental medicine · 1997Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fynTnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.