ArticleJournal of anatomy1995
Localisation of extracellular matrix components in the embryonic human notochord and axial mesenchyme.
Article in Journal of anatomy, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Gene expression in notochord and nuclei pulposi: a study of gene families across the chordate phylum.BMC ecology and evolution · 2023Article
- An insight on theFASEB bioAdvances · 2023Article
- Development of a straight vertebrate body axis.Development (Cambridge, England) · 2020Review
- Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Development of the axial skeleton and intervertebral disc.Current topics in developmental biology · 2019Review
- Review
- Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus.Scientific reports · 2017Article
- Notochord Cells in Intervertebral Disc Development and Degeneration.Journal of developmental biology · 2016Article
- Anterior-posterior regionalized gene expression in the Ciona notochord.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Notochordal cell-derived therapeutic strategies for discogenic back pain.Global spine journal · 2013Review
- Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Regulatory changes of N-acetylgalactosamine terminal sugar in early mouse embryonic paraxial mesenchyme.Cell journal · 2012Article
- Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2010Article
- Stepwise enforcement of the notochord and its intersection with the myoseptum: an evolutionary path leading to development of the vertebra?Journal of anatomy · 2006Article
- Increased fibronectin expression in developing embryos is associated with abnormal notochord in the Adriamycin rat model.Pediatric surgery international · 2004Article
- Intermediate filament typing of the human embryonic and fetal notochord.Cell and tissue research · 1995Article
- In vitro reconstructed tissues on hyaluronan-based temporary scaffolding.Journal of materials science. Materials in medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unsegmented axial mesenchyme is the first anlage of the embryonic vertebral column in amniotes. Its development and differentiation are influenced by the notochord. The appearance of extracellular matrix (ECM) components which may regulate the developmental processes in the human embryonic axial mesenchyme and the notochord was studied in 5 human embryos between Carnegie stages 12 and 14 (4th and early 5th gestational wk) by using Alcian blue histochemistry and immunohistochemistry with antibodies against types I and II collagens, the proteoglycans aggrecan, biglycan and decorin, the glycoproteins fibronectin, laminin and tenascin and the growth factor TGF-beta. The results demonstrate that the notochordal sheath contains high amounts of sulphated glycosaminoglycans, hyaluronic acid and the glycoproteins fibronectin, laminin and tenascin during all developmental stages examined. Additionally type II collagen and the small proteoglycan decorin were found. Type I collagen and the small proteoglycan biglycan could be detected in notochordal cells. The number of TGF-beta-immunoreactive notochordal cells increased between stages 12 and 14. The ECM of the axial mesenchyme is rich in sulphated glycosaminoglycans, hyaluronic acid, fibronectin and tenascin. Strong immunoreactions for collagen type I were found only during the early stage 12. The absence of aggrecan and keratan sulphate indicates that large aggregating proteoglycan complexes are missing. Epithelial-mesenchymal interactions which may be influenced by TGF-beta and the ECM components demonstrated are discussed.
Indexed as
Identifiers
7649807PMC1167277W242314439What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.