Evidence map›Paper›PMID 7649552›Full record

ArticleHuman genetics1995

Mapping of a human rRNA gene in the YAC contig surrounding the SMA candidate gene.

J Huschenbett, A Gasch, A Katzer, M Affeldt, A Speer

Abstract read
PubMed Publisher
In one paragraph

Article in Human genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

J HuschenbettJ. Medizinische Klinik, Universitätsklinikum Charité, Humboldt-Universität, Berlin, Germany.
A Gasch
A Katzer
M Affeldt
A Speer
Humboldt-Universität zu Berlin · DECharité - Universitätsmedizin Berlin · DEMax Delbrück Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using the yeast artificial chromosome (YAC) 116 flanking the autosomal recessive spinal muscular atrophy (SMA) gene region, we have screened a human fetal brain cDNA library and isolated the cDNA clone 14-3/9 with an insert size of 2.5 kb. The cDNA clone could be identified as part of the human rRNA gene coding for 28S rRNA with a total size of 5025 bp. The human 28S rRNA is involved in the organization of the 60S ribosomal subparticle and is arranged in a 13-kb pre-rRNA transcription unit that occurs in tandem repeat clusters. Multiple copies of the rRNA gene have been mapped by pulsed field blot hybridization in the YAC contig between YAC 66 and YAC 116, which encompasses the SMA candidate gene, and additionally in the distally localized YAC 153.

Indexed as

AdultBrain ChemistryChromosome MappingChromosomes, Artificial, YeastChromosomes, Human, Pair 5DNA, ComplementaryDNA, RibosomalElectrophoresis, Gel, Pulsed-FieldGenetic MarkersHumansMuscular Atrophy, SpinalRepetitive Sequences, Nucleic AcidRNA Processing, Post-TranscriptionalRNA, Ribosomal, 28SSpinal CordTranscription, GeneticDNA, ComplementaryDNA, RibosomalGenetic MarkersRNA, Ribosomal, 28S

Identifiers

PMID7649552
OpenAlexW2093329601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.