ArticleNature genetics1995
Localization of a gene for partial epilepsy to chromosome 10q.
Article in Nature genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Expanding clinical phenotype in CACNA1C related disorders: familial mesial temporal lobe epilepsy.Acta epileptologica · 2025Article
- Identification of autosomal dominant lateral temporal epilepsy caused by a novel mutation in RELN in China: a case report.Acta epileptologica · 2024Article
- LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic KNeurology(R) neuroimmunology & neuroinflammation · 2024Article
- A de novo pathogenic variant in MICAL-1 causes epilepsy with auditory features.Epilepsia open · 2024Article
- Nonsense mutation in DEPDC5 gene in a patient with carbamazepine-responsive focal epilepsy.Epilepsy & behavior reports · 2024Article
- Familial Mesial Temporal Lobe Epilepsy: Clinical Spectrum and Genetic Evidence for a Polygenic Architecture.Annals of neurology · 2023Article
- Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Review
- A novel LGI1 mutation causing autosomal dominant lateral temporal lobe epilepsy confirmed by a precise knock-in mouse model.CNS neuroscience & therapeutics · 2022Article
- Molecular typing of familial temporal lobe epilepsy.World journal of psychiatry · 2022Review
- The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Cellular and molecular life sciences : CMLS · 2021Review
- Epilepsy With Auditory Features: From Etiology to Treatment.Frontiers in neurology · 2021Review
- Functional Topography of Auditory Areas Derived From the Combination of Electrophysiological Recordings and Cortical Electrical Stimulation.Frontiers in human neuroscience · 2021Article
- Genetic Polymorphism ofFrontiers in neuroscience · 2020Article
- TheJournal of clinical medicine · 2019Review
- A genetic locus for sensory epilepsy precipitated by contact with hot water maps to chromosome 9p24.3-p23.Journal of genetics · 2018Article
- Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Disruption of the ATP/adenosine balance in CD39Immunology · 2017Article
- The clinical phenotype of autosomal dominant lateral temporal lobe epilepsy related to reelin mutations.Epilepsy & behavior : E&B · 2017Article
- Genetic and epigenetic mechanisms of epilepsy: a review.Neuropsychiatric disease and treatment · 2017Review
22 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.