Trial reportNutrition (Burbank, Los Angeles County, Calif.)
Glycerol gluconeogenesis in fasting humans.
Trial report in Nutrition (Burbank, Los Angeles County, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT02833415. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Visceral Adiposity and Diabetes: Translating Form to Function Using Imaging
Open the trial in the graphWho cites it
38 citing papers in PubMed, 104 citations in OpenAlex.
- Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis.Endocrine reviews · 2026Review
- Quantification of nutrient fluxes during acute exercise in mice.Cell metabolism · 2024Article
- Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes.American journal of physiology. Endocrinology and metabolism · 2023Article
- Study the Effect of Relative Energy Deficiency on Physiological and Physical Variables in Professional Women Athletes: A Randomized Controlled Trial.Metabolites · 2023Article
- Effects of 10-Day Complete Fasting on Physiological Homeostasis, Nutrition and Health Markers in Male Adults.Nutrients · 2022Article
- Article
- Glycerol contained in vaping liquids affects the liver and aspects of energy homeostasis in a sex-dependent manner.Physiological reports · 2022Article
- Histopathological and aquaporin7 mRNA expression analyzes in the skeletal and cardiac muscles of obese db/db mice.The Journal of veterinary medical science · 2021Article
- In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench.Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Tracking the carbons supplying gluconeogenesis.The Journal of biological chemistry · 2020Review
- Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes.Current diabetes reports · 2019Review
- Differential Transcriptomic and Metabolomic Responses in the Liver of Nile Tilapia (Oreochromis niloticus) Exposed to Acute Ammonia.Marine biotechnology (New York, N.Y.) · 2019Article
- Mechanisms of Insulin Action and Insulin Resistance.Physiological reviews · 2018Review
- The Role of Leptin in Maintaining Plasma Glucose During Starvation.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2018Article
- Stimulation of glycerol kinase in grass carp preadipocytes by EPA.Fish physiology and biochemistry · 2017Article
- Effects of visceral adiposity on glycerol pathways in gluconeogenesis.Metabolism: clinical and experimental · 2017Article
- The proliferation impairment induced by AQP3 deficiency is the result of glycerol uptake and metabolism inhibition in gastric cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Applications of stable, nonradioactive isotope tracers in in vivo human metabolic research.Experimental & molecular medicine · 2016Review
- Precursors of hexoneogenesis within the human mammary gland.American journal of physiology. Endocrinology and metabolism · 2015Article
- Influence of liver triglycerides on suppression of glucose production by insulin in men.The Journal of clinical endocrinology and metabolism · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The contribution of glycerol to glucose production has been measured in healthy volunteers by the simultaneous primed constant infusion of 1-[13C]glycerol and 3-[3H]glucose and the determination of the rates of appearance (Ra) of glycerol, glucose, and glycerol-derived glucose. In the postabsorptive state, glycerol Ra was 3.11 +/- 0.44 mumol.kg-1.min-1, of which 36% was converted to glucose, accounting for 4.5% of total glucose production. After 62-86 h of starvation, glycerol Ra rose to 5.32 +/- 0.58 mumol.kg-1.min-1, and 68% of glycerol was converted to glucose. This accounted for 21.6% of total glucose production. Glycerol Ra was closely correlated with its conversion and contribution to glucose. These findings confirm that the contribution of glycerol to glucose production is directly correlated to its release as a consequence of lipolysis and support the notion that the central physiological role of accelerated lipolysis in fasting is the provision of gluconeogenic precursor.
Indexed as
Identifiers
7647479W199935210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.