ArticleBiophysical journal1995
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 103 citations in OpenAlex.
- Deconstructing the integrated oscillator model for pancreatic β-cells.Mathematical biosciences · 2023Article
- Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Physiological reviews · 2018Review
- Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.The Journal of biological chemistry · 2015Article
- Mathematical models of electrical activity of the pancreatic β-cell: a physiological review.Islets · 2014Review
- The impact of mathematical modeling on the understanding of diabetes and related complications.CPT: pharmacometrics & systems pharmacology · 2013Article
- Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca(2+) concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line.Acta diabetologica · 2012Article
- Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study.The Journal of general physiology · 2011Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Lessons from models of pancreatic beta cells for engineering glucose-sensing cells.Mathematical biosciences · 2010Review
- AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.Molecular and cellular endocrinology · 2010Article
- Pancreatic islet cells: a model for calcium-dependent peptide release.HFSP journal · 2010Article
- A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.Biophysical journal · 2009Article
- Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.Endocrinology · 2009Article
- RyR channels and glucose-regulated pancreatic beta-cells.European biophysics journal : EBJ · 2008Article
- Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.PloS one · 2007Article
- Effects of both glucose and IP3 concentrations on action potentials in pancreatic beta-cells.European biophysics journal : EBJ · 2007Article
- Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.The Journal of physiology · 2005Article
- Filtering of calcium transients by the endoplasmic reticulum in pancreatic beta-cells.Biophysical journal · 2004Article
- Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels.The Journal of membrane biology · 2004Review
- Muscarinic agonists activate Ca2+ store-operated and -independent ionic currents in insulin-secreting HIT-T15 cells and mouse pancreatic beta-cells.The Journal of membrane biology · 2004Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.