ArticleBiophysical journal1995
Deformation and flow of red blood cells in a synthetic lattice: evidence for an active cytoskeleton.
Article in Biophysical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 62 citations in OpenAlex.
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip.Micromachines · 2020Review
- Biocompatible coupling of therapeutic fusion proteins to human erythrocytes.Blood advances · 2018Article
- Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- A microfabricated deformability-based flow cytometer with application to malaria.Lab on a chip · 2011Article
- Whole blood pumping with a microthrottle pump.Biomicrofluidics · 2010Article
- Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.MRS bulletin · 2010Article
- A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Parallel microchannel-based measurements of individual erythrocyte areas and volumes.Biophysical journal · 2003Article
- Biology on a chip: microfabrication for studying the behavior of cultured cells.Critical reviews in biomedical engineering · 2003Review
- Coupled multi-component systems: A simple membrane model.Journal of biological physics · 2002Article
- Beta-adrenergic agonists regulate cell membrane fluctuations of human erythrocytes.The Journal of physiology · 1999Article
- Influence of network topology on the elasticity of the red blood cell membrane skeleton.Biophysical journal · 1997Article
- Biotechnology at low Reynolds numbers.Biophysical journal · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We introduce the use of microfabrication techniques to construct on a silicon wafer a synthetic capillary bed with 2.5- to 4-micron (mu)-wide channels. Establishment of a fluid pressure gradient allowed us to observe simultaneously using optical microscopy hundreds of cells flowing through the bed at physiological speeds. We find a large distribution of mobilities among red cells flowing through the structure; smaller channels provide a greater impedance to flow than larger ones, indicating that kinetic drag variations provide the origin of the distribution. The mobility of a particular cell is not correlated with the cell diameter but appears to be inversely correlated with intracellular calcium concentration of the cell, as determined by fluorescence of the calcium-binding dye fluo-3 AM. Also, we are able to use the parallel processing nature of our arrays to observe isolated events where the rigidity of the red cell seems to change suddenly over several orders of magnitude as it blocks a channel in the array.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.