ArticleThe Biochemical journal1995
Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
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- Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression.PloS one · 2016Article
- Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of t-PA.International journal of vascular medicine · 2016Article
- Dynamic Enhancer Methylation--A Previously Unrecognized Switch for Tissue-Type Plasminogen Activator Expression.PloS one · 2015Article
- Histone deacetylase inhibition enhances tissue plasminogen activator release capacity in atherosclerotic man.PloS one · 2015Article
- Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes.Virulence · 2015Article
- Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model.PloS one · 2014Article
- Histone deacetylase inhibitors stimulate tissue-type plasminogen activator production in vascular endothelial cells.Journal of thrombosis and thrombolysis · 2013Article
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- Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling.PloS one · 2008Article
- Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes.Cytotechnology · 2007Article
- Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation.Molecular cancer · 2002Article
- Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1.The Journal of physiology · 2002Article
- Development and improvement of a serum-free suspension process for the production of recombinant adenoviral vectors using HEK293 cells.Cytotechnology · 2001Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the pleiotropic agent sodium butyrate strongly stimulates tissue-type plasminogen activator (t-PA) expression in human umbilical vein endothelial cells (HUVEC). Here we provide the following evidence that the butyrate-induced t-PA expression in HUVEC involves histone H4 acetylation. (1) t-PA induction by butyrate occurs at the transcriptional level and does not require new protein synthesis, indicating a direct effect. (2) t-PA induction by butyrate can be fully mimicked by a specific, structurally unrelated, histone deacetylase inhibitor, trichostatin A. (3) At optimally stimulatory conditions, a combination of butyrate and trichostatin A does not enhance t-PA production more than each of the compounds alone, indicating that both compounds act through a common regulatory mechanism. (4) Induction of t-PA transcription by butyrate and trichostatin A was found to be preceded by histone H4 acetylation; at suboptimal inducing concentrations of butyrate and trichostatin A, the degree of acetylation of histone H4 caused by each agent was similarly reduced. These results are consistent with a role for histone H4 acetylation in t-PA induction by butyrate in HUVEC.
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