ArticleAnatomy and embryology1995
Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos.
Article in Anatomy and embryology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 114 citations in OpenAlex.
- Deletion of aJOR spine · 2026Article
- A Spatio-Temporal-Dependent Requirement of Sonic Hedgehog in the Early Development of Sclerotome-Derived Vertebrae and Ribs.International journal of molecular sciences · 2024Article
- Article
- An overview of PAX1: Expression, function and regulation in development and diseases.Frontiers in cell and developmental biology · 2022Review
- Somite development in the avian tail.Journal of anatomy · 2019Article
- Developmental dynamics of occipital and cervical somites.Journal of anatomy · 2016Article
- Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.PLoS genetics · 2013Article
- Temporal sequence in the formation of midline dermis and dorsal vertebral elements in avian embryos.Journal of anatomy · 2012Article
- The generation of vertebral segmental patterning in the chick embryo.Journal of anatomy · 2012Article
- Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Commitment of chondrogenic precursors of the avian scapula takes place after epithelial-mesenchymal transition of the dermomyotome.BMC developmental biology · 2010Article
- Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation.Developmental biology · 2009Article
- Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Birth defects research. Part B, Developmental and reproductive toxicology · 2007Review
- Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.Genes & development · 1999Article
- Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling.Genes & development · 1999Article
- Notochord repression of endodermal Sonic hedgehog permits pancreas development.Genes & development · 1998Article
- Axial structures control laterality in the distribution pattern of endothelial cells.Anatomy and embryology · 1996Article
- Pax-1 in the development of the cervico-occipital transitional zone.Anatomy and embryology · 1995Article
- Early stages of chick somite development.Anatomy and embryology · 1995Review
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pax-1 encodes for a DNA-binding transcriptional activator that was originally discovered in murine embryos using a probe from the Drosophila paired-box-containing gene, gooseberry-distal. We have cloned the avian Pax-1 gene as a basis for experimental studies of the induction of Pax-1 in the paraxial mesoderm. The amino acid sequence of the paired-domain is exactly the same in the quail and mouse, whereas outside the paired-domain there is 61% homology. Starting at about the eight-somite stage, quail Pax-1 is expressed in the paraxial mesoderm in a craniocaudal sequence. The unsegmented paraxial mesoderm and the two most recently formed somites do not express Pax-1. In the epithelial somite, the somitocoele cells and the cells of the ventral two-thirds of the epithelial wall are positive. As soon as the sclerotome is formed, only a subset of sclerotome cells expresses Pax-1. These are the cells that migrate towards the notochord to form the perinotochordal tube. Expression then becomes restricted to the intervertebral discs, the perichondrium of the vertebral bodies and the connective tissue surrounding the spinal ganglia. Additional expression domains are found in the scapula and the pelvic region, distinct areas of the head, and the epithelium of the second to the fourth visceral pouch. In later stages the thymus is positive. In vitro and in vivo experiments show that the notochord induces Pax-1 in the paraxial mesoderm, but limb bud mesoderm is not competent to respond to notochordal signals. Floor plate is also capable of inducing Pax-1 expression in sclerotome cells. Our studies show that in competent cells of the paraxial mesoderm, Pax-1 is a mediator of signals emanating from the notochord and the floor plate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.