ArticleProceedings of the National Academy of Sciences of the United States of America1995
The yeast nuclear import receptor is required for mitosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 152 citations in OpenAlex.
- Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5).Biomolecules · 2023Article
- Karyopherin-mediated nucleocytoplasmic transport.Nature reviews. Molecular cell biology · 2022Review
- TheeLife · 2019Article
- Nuclear Transport of Yeast Proteasomes.Frontiers in molecular biosciences · 2019Review
- Septin-associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Nuclear import of dimerized ribosomal protein Rps3 in complex with its chaperone Yar1.Scientific reports · 2016Article
- Rapidly Translated Polypeptides Are Preferred Substrates for Cotranslational Protein Degradation.The Journal of biological chemistry · 2016Article
- Nuclear Import of Yeast Proteasomes.Cells · 2015Review
- Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.The Journal of cell biology · 2015Article
- Neurospora importin α is required for normal heterochromatic formation and DNA methylation.PLoS genetics · 2015Article
- Yeast importin-α (Srp1) performs distinct roles in the import of nuclear proteins and in targeting proteasomes to the nucleus.The Journal of biological chemistry · 2014Article
- Nuclear import factor Srp1 and its associated protein Sts1 couple ribosome-bound nascent polypeptides to proteasomes for cotranslational degradation.The Journal of biological chemistry · 2014Article
- The intrinsically disordered N-terminal region of AtREM1.3 remorin protein mediates protein-protein interactions.The Journal of biological chemistry · 2012Article
- Interaction with the histone chaperone Vps75 promotes nuclear localization and HAT activity of Rtt109 in vivo.Traffic (Copenhagen, Denmark) · 2011Article
- Article
- Yeast karyopherin Kap95 is required for cell cycle progression at Start.BMC cell biology · 2010Article
- Nap1 and Chz1 have separate Htz1 nuclear import and assembly functions.Traffic (Copenhagen, Denmark) · 2010Article
- Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.Retrovirology · 2009Article
- Calmodulin-driven nuclear entry: trigger for sex determination and terminal differentiation.The Journal of biological chemistry · 2009Review
- Nuclear shuttling of She2p couples ASH1 mRNA localization to its translational repression by recruiting Loc1p and Puf6p.Molecular biology of the cell · 2009Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The nuclear import system is highly conserved among eukaryotes. Here we report the effects of a conditional mutation in SRP1, which encodes a Saccharomyces cerevisiae homolog of the vertebrate nuclear import receptor importin. Importin was isolated as a factor required for the initial targeting step of a nuclear import substrate to the nuclear envelope in a mammalian in vitro assay. We show that yeast Srp1 is similarly required for protein import. In addition, Srp1 is also required for the execution of mitosis: we demonstrate that cells containing a conditional mutation of SRP1 arrest with a G2/M phenotype in a manner analogous to classic cdc mutants. This defect may be due to the failure of the mutant to degrade the mitotic cyclin Clb2 and other proteins required for mitosis. The requirement of a nuclear import receptor for cell cycle-regulated proteolysis implies that import of cell cycle regulators into the nucleus is critical for cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.