ArticleJournal of molecular evolution1995
Evolution of protamine P1 genes in mammals.
Article in Journal of molecular evolution, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 93 citations in OpenAlex.
- Protamines and the sperm nuclear basic proteins Pandora's Box of insects.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2024Article
- Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1.Nature structural & molecular biology · 2023Article
- The Art of Packaging the Sperm Genome: Molecular and Structural Basis of the Histone-To-Protamine Exchange.Frontiers in endocrinology · 2022Review
- Sperm bauplan and function and underlying processes of sperm formation and selection.Physiological reviews · 2022Review
- Oxidation of Sperm DNA and Male Infertility.Antioxidants (Basel, Switzerland) · 2021Review
- Entropy based analysis of vertebrate sperm protamines sequences: evidence of potential dityrosine and cysteine-tyrosine cross-linking in sperm protamines.BMC genomics · 2020Article
- Two arginine residues suppress the flexibility of nucleosomal DNA in the canonical nucleosome core.PloS one · 2015Article
- Sexual selection on protamine and transition nuclear protein expression in mouse species.Proceedings. Biological sciences · 2014Article
- A comparison of DNA compaction by arginine and lysine peptides: a physical basis for arginine rich protamines.Biochemistry · 2013Article
- Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study.Journal of endocrinological investigation · 2012Article
- Extraordinary sequence divergence at Tsga8, an X-linked gene involved in mouse spermiogenesis.Molecular biology and evolution · 2011Article
- Comparative analysis of testis protein evolution in rodents.Genetics · 2008Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protamine P1 genes have been sequenced following PCR amplification from 11 mammals representing five major mammalian orders: Rodentia (rat and guinea pig), Carnivora (cat and bear), Proboscidea (elephant), Perissodactyla (horse), and Artiodactyla (camel, deer, elk, moose, and gazelle). The predicted amino acid sequence for these genes together with previously reported sequences results in a data set of 25 different P1 genes and 30 different P1 amino acid sequences. The alignment of all these sequences reveals that protamines are amongst the most rapidly diverging proteins studied. In spite of the large number of differences there are conserved motifs that are also common to birds such as the N-terminal ARYR followed by the triple alternating SRSRSR phosphorylation site. The central region contains 3 arginine clusters consisting of 5-6 arginines each. The C-terminus appears to be the most variable region of the protamines. Overall the molecular evolution of P1 genes is in agreement with the expected species evolution supporting that these genes have evolved vertically.
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