ArticleJournal of medical genetics1995
Association study with two markers of a human homeogene in infantile autism.
Article in Journal of medical genetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Article
- Functional Outcomes of Cerebellar Malformations.Frontiers in cellular neuroscience · 2019Review
- Clinical Phenotypes Associated to Engrailed 2 Gene Alterations in a Series of Neuropediatric Patients.Frontiers in neuroanatomy · 2018Article
- Autism spectrum disorder-associated genes and the development of dentate granule cells.Medical molecular morphology · 2017Review
- Role of Genetics in the Etiology of Autistic Spectrum Disorder: Towards a Hierarchical Diagnostic Strategy.International journal of molecular sciences · 2017Review
- Knowledge-Guided Bioinformatics Model for Identifying Autism Spectrum Disorder Diagnostic MicroRNA Biomarkers.Scientific reports · 2016Article
- Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior.Human molecular genetics · 2015Article
- Autism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum.PloS one · 2014Article
- Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum.Reviews in the neurosciences · 2014Review
- Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population.Genetics and molecular biology · 2013Article
- Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research.Frontiers in systems neuroscience · 2013Article
- Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.Human molecular genetics · 2012Article
- Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice.PloS one · 2012Article
- An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males.Molecular autism · 2011Article
- Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.Biological psychiatry · 2009Article
- Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate.Neuroscience · 2009Article
- The mouse Engrailed genes: a window into autism.Behavioural brain research · 2007Article
- The genetics of autistic disorders and its clinical relevance: a review of the literature.Molecular psychiatry · 2007Review
- Review
- The genetics of autism spectrum disorders.Neuromolecular medicine · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological data and family studies in autism show that there is a genetic susceptibility factor in the aetiology of this syndrome. We carried out an association study in infantile autism. Two markers of the homeogene EN2 involved in cerebellar development were tested in a population of 100 autistic children and in a population of 100 control children. With the MP4 probe showing a PvuII polymorphism, significant differences in the allele frequencies between the two populations were found (chi 2 = 7.99, df = 1, p < 0.01). With the MP5 probe showing an SstI polymorphism, no difference appeared (chi 2 = 1.17, not significant). Several clinical examinations allowed us to characterise the autistic children. Most of them had high scores for autistic behaviour and language disorders but low scores for neurological syndromes. Two children had a significant family history and six children had confirmed syndromes or diseases of genetic origin. Discriminant analysis between clinical and molecular data did not give significant results. These preliminary results must be supported by further analyses of this gene and by studies of its potential involvement in the pathophysiology of the autistic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.