ArticleThe Journal of cell biology1995
Hst-1 (FGF-4) antisense oligonucleotides block murine limb development.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- Self-organized formation of developing appendages from murine pluripotent stem cells.Nature communications · 2019Article
- HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity.Oncogene · 2002Article
- Detection of spatial localization of Hst-1/Fgf-4 gene expression in brain and testis from adult mice.Oncogene · 2000Article
- Adenovirus-mediated transfer of HST-1/FGF-4 gene protects mice from lethal irradiation.Oncogene · 1999Article
- A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth.Genes & development · 1998Article
- Apoptosis in the chick wing bud and the permanence of FGF-2 rescue.In vitro cellular & developmental biology. Animal · 1998Article
- A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initiation of limb development depends on the site specific proliferation of the mesenchyme by the signals from the apical ectodermal ridge (AER) in embryonic mouse. We have previously reported that the local expression of Hst-1/Fgf-4 transcripts in AER of the mouse limb bud is developmentally regulated, expressed at 11 and 12 days post coitus (p.c.) embryo. In an effort to further understand the role of Hst-1/FGF-4 in mouse limb development, an antisense oligodeoxynucleotides (ODNs) study was performed. We first established a novel organ culture system to study mouse limb development in vitro. This system allows mouse limb bud at 9.5-10-d p.c. embryo, when placed on a sheet of extracellular matrix in a defined medium, to differentiate into a limb at 12.5-d p.c. embryo within 4.5 d. Using this organ culture system, we have shown that exposure of 9.5-10-d p.c. embryonal limb bud explants to antisense ODNs of Hst-1/FGF-4 blocks limb development. In contrast, sense and scrambled ODNs have no inhibitory effect on limb outgrowth, suggesting that Hst-1/FGF-4 may work as a potent inducing factor for mouse limb development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.