ArticleThe Journal of cell biology1995
Fish E587 glycoprotein, a member of the L1 family of cell adhesion molecules, participates in axonal fasciculation and the age-related order of ganglion cell axons in the goldfish retina.
Article in The Journal of cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis.Open biology · 2016Article
- Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells.Investigative ophthalmology & visual science · 2011Article
- The promotive effects of thymosin beta4 on neuronal survival and neurite outgrowth by upregulating L1 expression.Neurochemical research · 2008Article
- Intraretinal projection of retinal ganglion cell axons as a model system for studying axon navigation.Brain research · 2008Review
- Molecular mechanisms of optic axon guidance.Die Naturwissenschaften · 2005Review
- The L1 cell adhesion molecule is essential for topographic mapping of retinal axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment.The Journal of cell biology · 2000Article
- The receptor tyrosine phosphatase CRYPalpha promotes intraretinal axon growth.The Journal of cell biology · 1999Article
- Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.The Journal of cell biology · 1999Article
- Neurolin Ig domain 2 participates in retinal axon guidance and Ig domains 1 and 3 in fasciculation.The Journal of cell biology · 1999Article
- Neurolin, the goldfish homolog of DM-GRASP, is involved in retinal axon pathfinding to the optic disk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.The Journal of cell biology · 1997Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Axons derived from young ganglion cells in the periphery of the retinae of larval and adult goldfish are known to fasciculate with one another and their immediate forerunners, creating the typical age-related order in the retinotectal pathway. Young axons express the E587 antigen, a member of the L1 family of cell adhesion molecules. Repeated injections of Fab fragments from a polyclonal E587 antiserum (E587 Fabs) into the eye of 3.4 cm goldfish disrupted the orderly fascicle pattern of RGC axons in the retina which was preserved in controls. Instead of bundling tightly, RGC axons crossed one another, grew between fascicles and arrived at the optic disk in a broadened front. When added to RGC axons growing in vitro, E587 Fabs neutralized the preference of growth cones to elongate on lanes of E587 protein, caused defasciculation of axons which normally prefer to grow along each other when explanted on polylysine, and prevented clustering of E587 antigen at axon-axon contact sites. Monoclonal E587 antibody disturbed axonal fasciculation moderately but led to a 30% reduction in growth velocities when axons tracked other axons. Therefore we conclude that E587 antigen mediates axonal recognition, selective fasciculation and the creation of the age-related order in the fish retina.
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