ArticleInfection and immunity1995
Interaction of Listeria monocytogenes with mouse dendritic cells.
Article in Infection and immunity, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 121 citations in OpenAlex.
- Heparin-binding enhances extracellular listeriolysin O activity, overcoming cholesterol inhibition and pH dependence.Journal of bacteriology · 2026Article
- Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.Cellular and molecular life sciences : CMLS · 2019Article
- Article
- The Influence of the Toxin/Antitoxin mazEF on Growth and Survival of Listeria monocytogenes under Stress.Toxins · 2017Article
- Sublethal Concentrations of Antibiotics Cause Shift to Anaerobic Metabolism in Listeria monocytogenes and Induce Phenotypes Linked to Antibiotic Tolerance.Frontiers in microbiology · 2016Article
- RNA Helicase Important for Listeria monocytogenes Hemolytic Activity and Virulence Factor Expression.Infection and immunity · 2016Article
- RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.The EMBO journal · 2012Article
- Ether lipid vesicle-based antigens impart protection against experimental listeriosis.International journal of nanomedicine · 2012Article
- microRNA response to Listeria monocytogenes infection in epithelial cells.International journal of molecular sciences · 2012Article
- Association of ActA to peptidoglycan revealed by cell wall proteomics of intracellular Listeria monocytogenes.The Journal of biological chemistry · 2011Article
- Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton.The Journal of cell biology · 2011Review
- Galleria mellonella as a model system for studying Listeria pathogenesis.Applied and environmental microbiology · 2010Article
- Quantitative phosphokinome analysis of the Met pathway activated by the invasin internalin B from Listeria monocytogenes.Molecular & cellular proteomics : MCP · 2009Article
- ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes.Infection and immunity · 2007Article
- Construction of a multiple fluorescence labelling system for use in co-invasion studies of Listeria monocytogenes.BMC microbiology · 2006Article
- A homolog of Bacillus subtilis trigger factor in Listeria monocytogenes is involved in stress tolerance and bacterial virulence.Applied and environmental microbiology · 2006Article
- Human dendritic cells process and present Listeria antigens for in vitro priming of autologous CD4+ T lymphocytes.Histochemistry and cell biology · 2005Article
- Growth, virulence, and immunogenicity of Listeria monocytogenes aro mutants.Infection and immunity · 2004Article
- Oral immunization with recombinant listeria monocytogenes controls virus load after vaginal challenge with feline immunodeficiency virus.Journal of virology · 2004Article
- Primary dendritic cells phagocytose Cryptococcus neoformans via mannose receptors and Fcgamma receptor II for presentation to T lymphocytes.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the interaction of murine dendritic cells with Listeria monocytogenes was investigated. Dendritic cells are efficient antigen-presenting cells, play a key role in the immune response, and are capable of migrating over substantial distances between sites of infection and lymphoid tissues. L. monocytogenes EGD invaded dendritic cells, escaped from phagosomes into the cytoplasm, and there directed actin nucleation, polymerization, and polarization in a typical fashion, thereby achieving intracellular movement and cell-to-cell spread. The internalization process appears to be independent of the inl locus. Interestingly, an intact microtubular function was essential for efficient uptake, whereas in a previous report, microtubule disruption did not affect bacterial spread in Caco-2 cells. The results obtained also suggest that L. monocytogenes binds to glycosylated receptors of dendritic cells. Uptake of Listeria cells was mediated by a protein kinase-dependent transducing phosphorylation signal that induces the actin polymerization-dependent phagocytic process. To achieve efficient uptake, de novo protein synthesis of eukaryotic and prokaryotic cells is also required. Despite the killing of dendritic cells, wild-type bacteria were found to persist in small numbers in some cells for at least 24 h. When different isogenic mutants of the EGD strain were analyzed for their capability to interact with dendritic cells, it was observed that some virulence-attenuated mutants (i.e., prfA and delta hly) persisted in large numbers for even longer times. Invasion of dendritic cells by L. monocytogenes, which in turn could result in either cell death or persistent infection, might have an important role in the pathogenesis of listeriosis, leading to impaired immune responses with inefficient bacterial clearance and/or promoting bacterial spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.