ArticleImmunogenetics1995
Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species.
Article in Immunogenetics, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 88 citations in OpenAlex.
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- T Cell Receptor Alpha Chain Genes in the Teleost Ballan WrasseFrontiers in immunology · 2018Article
- Identification and characterization of TCRγ and TCRδ chains in channel catfish, Ictalurus punctatus.Immunogenetics · 2014Article
- Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.Developmental and comparative immunology · 2014Review
- Article
- The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realities.Immunogenetics · 2011Review
- The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.European journal of immunology · 2010Article
- Recognition of additional roles for immunoglobulin domains in immune function.Seminars in immunology · 2010Review
- The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains.BMC evolutionary biology · 2008Article
- Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.Immunologic research · 2007Article
- The path from molecular indicators of exposure to describing dynamic biological systems in an aquatic organism: microarrays and the fathead minnow.Ecotoxicology (London, England) · 2003Review
- A novel multigene family encodes diversified variable regions.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves.The Journal of experimental medicine · 1997Article
- Characterization of avian T-cell receptor gamma genes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Pufferfish and new paradigm for comparative genome analysis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The structure, rearrangement, and ontogenic expression of DB and JB gene segments of the Mexican axolotl T-cell antigen receptor beta chain (TCRB).Immunogenetics · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Characterization of the structure, multiplicity, organization, and cell lineage-specific expression of T-cell receptor (TCR) genes of nonmammalian vertebrate species is central to the understanding of the evolutionary origins of rearranging genes of the vertebrate immune system. We recently described a polymerase chain reaction (PCR) strategy that relies on short sequence similarities shared by nearly all vertebrate TCR and immunoglobulin (Ig) variable (V) regions and have used this approach to isolate a TCR beta (TCRB) homolog from a cartilaginous fish. Using these short PCR products as probes in spleen cDNA and genomic libraries, we were able to isolate a variety of unique TCR and TCR-like genes. Here we report the identification and characterization of a chicken TCR gamma (TCRG) homolog, apparent Xenopus and pufferfish TCR alpha (TCRA) homologs, and two horned shark TCR delta (TCRD)-like genes. In addition, we have identified what could be a novel representative of the Ig gene superfamily in the pufferfish. This method of using short, minimally degenerate PCR primers should speed progress in the phylogenetic investigations of the TCR and related genes and lend important insights into both the origins and functions of these unique gene systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.