ArticleImmunology1995
IL-2 and IL-7 but not IL-12 protect natural killer cells from death by apoptosis and up-regulate bcl-2 expression.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Cytokines in Focus: IL-2 and IL-15 in NK Adoptive Cell Cancer Immunotherapy.Immune network · 2025Review
- Article
- Inhalation of panaxadiol alleviates lung inflammationJournal of ginseng research · 2024Article
- Cord blood derived NK cells activated in counter with tumor cells.Cell and tissue banking · 2023Article
- Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential.Cancers · 2022Review
- Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.The Journal of experimental medicine · 2017Article
- Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies-A review.Oncoimmunology · 2015Review
- Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus.Frontiers in neurology · 2015Review
- Interleukin-7 expression and its effect on natural killer cells in patients with multiple sclerosis.Journal of neuroimmunology · 2014Article
- Exogenous amino acids are essential for interleukin-7 induced CD8 T cell growth. [corrected].PloS one · 2012Article
- A prostate cancer vaccine comprising whole cells secreting IL-7, effective against subcutaneous challenge, requires local GM-CSF for intra-prostatic efficacy.Cancer immunology, immunotherapy : CII · 2009Article
- Interleukin-15 enhances cytotoxicity, receptor expression, and expansion of neonatal natural killer cells in long-term culture.Clinical and diagnostic laboratory immunology · 2004Article
- Effect of interleukin (IL)-12 and IL-15 on apoptosis and proliferation of umbilical cord blood mononuclear cells.Bone marrow transplantation · 2001Article
- Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells.British journal of cancer · 1998Article
- Enhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2 (IL-2) and IL-12.Clinical and diagnostic laboratory immunology · 1998Article
- Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Evaluation of the BCL-2 gene locus as a susceptibility locus linked to the clinical expression of systemic lupus erythematosus (SLE).Rheumatology international · 1996Article
- Gene fusion of IL7 involved in the regulation of idiopathic pulmonary fibrosis.Therapeutic advances in respiratory diseaseArticle
- Apoptosis in the heart: when and why?Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human natural killer cells (NK) respond to interleukin-2 (IL-2) with augmented cytolytic activity, cytokine secretion and cell proliferation. Here we show that IL-2 protects NK cells from death by apoptosis (programmed cell death; PCD). Highly purified NK cells (CD3- CD56+) were isolated from peripheral blood lymphocytes (PBL) of either control donors or of an asymptomatic donor with 60% NK cells. Glucocorticosteroids (GCS) induced PCD in NK cells, as shown by nuclear condensation and DNA fragmentation. IL-2 completely prevented GCS-induced PCD in a dose-dependent manner without overcoming GCS-induced inhibition of NK cell proliferation. The IL-2 protective effect was mediated through the p75 beta chain of the IL-2R, as neutralizing monoclonal antibody (mAb) to the p75 beta chain but not to the p55 alpha chain completely abolished the IL-2 anti-apoptotic activity. In addition to IL-2, the cytokines IL-7 and IL-12 have been reported to regulate NK cell functions. Our present data showed that IL-7 but not IL-12 rescued NK cells from apoptosis, but to a lesser extent than IL-2. Although IL-4 had a marginal protective effect, IL-1, IL-3, IL-6, IL-8, interferon-gamma (IFN-gamma) and IFN-alpha, tumour necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta) and granulocyte-macrophage colony-stimulating factor (GM-CSF) displayed no significant activity. Finally, we report that IL-2 and IL-7 enhanced bcl-2 expression in NK cells, suggesting the existence of a bcl-2-dependent survival pathway. In addition to regulating various functions, it is concluded that IL-2 and IL-7 have the ability to prevent PCD in NK cells.
Indexed as
Identifiers
7642225PMC1383900What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.