ArticleThe EMBO journal1995
Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 131 citations in OpenAlex.
- Donor noradrenaline use is associated with better allograft survival in recipients of pancreas transplantation.Annals of the Royal College of Surgeons of England · 2024Article
- Role of G-proteins in islet function in health and diabetes.Diabetes, obesity & metabolism · 2017Review
- Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences.Frontiers in molecular neuroscience · 2017Review
- Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.The Journal of biological chemistry · 2015Article
- Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Identification of an in vitro interaction between an insect immune suppressor protein (CrV2) and G alpha proteins.The Journal of biological chemistry · 2011Article
- Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.Diabetes · 2010Article
- Molecular mechanisms of go signaling.Neuro-Signals · 2009Review
- A specific role of AGS3 in the surface expression of plasma membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The calcium-sensing protein synaptotagmin 7 is expressed on different endosomal compartments in endocrine, neuroendocrine cells or neurons but not on large dense core vesicles.Histochemistry and cell biology · 2007Article
- Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis.Biochimica et biophysica acta · 2007Review
- Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells.British journal of pharmacology · 2002Article
- Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.The Journal of physiology · 2000Review
- P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila.The Journal of cell biology · 1999Article
- SNAP-25a and -25b isoforms are both expressed in insulin-secreting cells and can function in insulin secretion.The Biochemical journal · 1999Article
- Regulation of exocytosis from rat peritoneal mast cells by G protein beta gamma-subunits.The EMBO journal · 1998Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exocytotic release of potent hormones is a tightly controlled process. Its direct regulation without the involvement of second messengers would ensure rapid signal processing. In streptolysin O-permeabilized insulin-secreting cells, a preparation allowing dialysis of cytosolic macromolecules, activation of alpha 2-adrenergic receptors caused pertussis toxin-sensitive inhibition of calcium-induced exocytosis. This inhibition was mimicked very efficiently by the use of specific receptor-mimetic peptides, indicating the involvement of Gi and, to a lesser extent, of G(o). The regulation was exerted beyond the ATP-dependent step of exocytosis. In addition, low nanomolar amounts of pre-activated Gi/G(o) directly inhibited exocytosis. As transient overexpression of constitutively active mutants of G alpha i1, G alpha i2, G alpha i3 and G alpha o2 but not of G alpha o1 reproduced this regulation, the G alpha subunit alone is sufficient to induce inhibition. These results define exocytosis as an effector for heterotrimeric G-proteins and delineate the properties of the transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.