ArticleClinical & experimental metastasis1995
Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.
Article in Clinical & experimental metastasis, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence.Cancer immunology, immunotherapy : CII · 2025Article
- The DNA repair kinase ATM regulates CD13 expression and cell migration.Frontiers in cell and developmental biology · 2024Article
- NGR-Based Radiopharmaceuticals for Angiogenesis Imaging: A Preclinical Review.International journal of molecular sciences · 2023Review
- Development of Hydroxamate Derivatives Containing a Pyrazoline Moiety as APN Inhibitors to Overcome Angiogenesis.Molecules (Basel, Switzerland) · 2022Article
- Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go?Cancers · 2022Review
- Article
- Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs.Oncotarget · 2018Article
- Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells.Chemical science · 2017Article
- Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.Scientific reports · 2017Article
- Exploring ligand dissociation pathways from aminopeptidase N using random acceleration molecular dynamics simulation.Journal of molecular modeling · 2016Article
- Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.Clinics and research in hepatology and gastroenterology · 2016Article
- Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice.Experimental eye research · 2016Article
- The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.PloS one · 2016Article
- MT95-4, a fully humanized antibody raised against aminopeptidase N, reduces tumor progression in a mouse model.Cancer science · 2015Article
- A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy.The Journal of biological chemistry · 2014Article
- Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression.Molecular pharmaceutics · 2014Article
- Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients.Clinical & experimental metastasis · 2014Article
- Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.Bioorganic & medicinal chemistry letters · 2013Article
- Aminopeptidase N (CD13) is involved in phagocytic processes in human dendritic cells and macrophages.BioMed research international · 2013Article
- CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aminopeptidase N/CD13 is a Zn(2+)-dependent exoprotease present on the cell surface as a transmembrane protein. Our previous studies using aminopeptidase inhibitors and antibodies demonstrated that aminopeptidase N is involved in the degradation and invasion of the extracellular matrix (ECM) by metastatic tumor cells. In the present study we transfected human A375M melanoma cells with eukaryotic plasmid expression vectors that contained full length cDNA of aminopeptidase N/CD13 and examined their characteristics. The transfectants that expressed extremely high levels of aminopeptidase N/CD13 degraded type IV collagen and invaded ECM more actively than the parental and control vector-transfected cells. Furthermore, the aminopeptidase N/CD13-transfected A375M cells had significantly augmented lung colonizing potential in nude mice. The results show that the aminopeptidase N/CD13 plays an active role in degradation and invasion of ECM and may be involved in the molecular mechanisms of blood-borne metastasis.
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