ArticleBritish journal of cancer1995
Chromosome 11 allele imbalance and clinicopathological correlates in ovarian tumours.
Article in British journal of cancer, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
- Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers.Cancer gene therapy · 2021Review
- Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells.Cell cycle (Georgetown, Tex.) · 2013Article
- Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors.Gynecologic oncology · 2009Article
- Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells.Oncogene · 2005Article
- Article
- Estrogen, progesterone and epithelial ovarian cancer.Reproductive biology and endocrinology : RB&E · 2003Review
- The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- RARRES3 expression positively correlated to tumour differentiation in tissues of colorectal adenocarcinoma.British journal of cancer · 2003Article
- Somatic mutations of the PPP2R1B candidate tumor suppressor gene at chromosome 11q23 are infrequent in ovarian carcinomas.Neoplasia (New York, N.Y.) · 1999Article
- 11q23.1 and 11q25-qter YACs suppress tumour growth in vivo.Oncogene · 1999Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epithelial ovarian cancers (EOCs). Forty EOCs (85%) showed allele imbalance at one or more loci, and in 39 of these (83%) the data suggested subchromosomal deletions: eight of 11p only; six of 11q only; and 25 of both 11p and 11q. Three consensus regions of deletion were indicated at 11p15.5-p15.3, 11q12-q22 and 11q23.3-q24.1. Allele imbalance at the 11q subtelomeric region (D11S912) correlated significantly with adverse survival, while imbalance at 11q14.3 and retention of heterozygosity at 11q22 (close to the site of the progesterone receptor gene) were associated with favourable clinicopathological features. The findings allow development of a preliminary model for the molecular evolution of epithelial ovarian cancer.
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