ArticleThe Biochemical journal1995
The regulatory protein of glucokinase binds to the hepatocyte matrix, but, unlike glucokinase, does not translocate during substrate stimulation.
Article in The Biochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
- Insulin Regulation of Hepatic Lipid Homeostasis.Comprehensive Physiology · 2023Review
- Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.Scientific reports · 2018Article
- Genetic effects on hypertriglyceridemic waist phenotype:International journal of clinical and experimental pathology · 2017Article
- The role of tanycytes in hypothalamic glucosensing.Journal of cellular and molecular medicine · 2015Review
- Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Current opinion in lipidology · 2015Review
- Dynamic localization of glucokinase and its regulatory protein in hypothalamic tanycytes.PloS one · 2014Article
- Assessing the potential of glucokinase activators in diabetes therapy.Nature reviews. Drug discovery · 2009Review
- New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.The Biochemical journal · 2002Review
- Investigation of the mechanism by which glucose analogues cause translocation of glucokinase in hepatocytes: evidence for two glucose binding sites.The Biochemical journal · 2000Article
- Long-term maintenance of low concentrations of fructose for the study of hepatic glucose phosphorylation.The Biochemical journal · 1999Article
- Specific features of glycogen metabolism in the liver.The Biochemical journal · 1998Review
- Subcellular distribution of hexokinase isoenzymes in pancreatic islet cells exposed to digitonin after incubation at a low or high concentration of D-glucose.Molecular and cellular biochemistry · 1997Article
- Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.The Biochemical journal · 1997Article
- Involvement of glucokinase translocation in the mechanism by which resorcinol inhibits glycolysis in hepatocytes.The Biochemical journal · 1997Article
- Investigation on the mechanism by which fructose, hexitols and other compounds regulate the translocation of glucokinase in rat hepatocytes.The Biochemical journal · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetic properties of hepatic glucokinase (hexokinase IV) are modulated by binding to a regulatory protein. This study shows that, in hepatocytes incubated with 5 mM glucose as sole carbohydrate substrate, both glucokinase and its regulatory protein bind to the cell matrix by a Mg(2+)-dependent mechanism. After incubation with an elevated [glucose] or with fructose, glucokinase, but not its regulatory protein, translocates from the Mg(2+)-dependent binding site. It is suggested that the regulatory protein acts as a receptor for anchoring glucokinase to the hepatocyte matrix and inhibiting its activity in metabolically quiescent conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.