ArticleProceedings of the National Academy of Sciences of the United States of America1995
Identification of planarian homeobox sequences indicates the antiquity of most Hox/homeotic gene subclasses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 59 citations in OpenAlex.
- Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals.Nature communications · 2021Article
- Xenacoelomorpha Survey Reveals That All 11 Animal Homeobox Gene Classes Were Present in the First Bilaterians.Genome biology and evolution · 2018Article
- An Overview ofJournal of developmental biology · 2016Review
- Article
- Genomic organization and expression demonstrate spatial and temporal Hox gene colinearity in the lophotrochozoan Capitella sp. I.PloS one · 2008Article
- Hox genes from the earthworm Perionyx excavatus.Development genes and evolution · 2003Article
- HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.The American journal of pathology · 2001Article
- Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Classification and phylogeny of the MADS-box multigene family suggest defined roles of MADS-box gene subfamilies in the morphological evolution of eukaryotes.Journal of molecular evolution · 1996Article
- Identification of members of several homeobox genes in a planarian using a ligation-mediated polymerase chain reaction technique.Nucleic acids research · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The homeotic gene complex (HOM-C) is a cluster of genes involved in the anteroposterior axial patterning of animal embryos. It is composed of homeobox genes belonging to the Hox/HOM superclass. Originally discovered in Drosophila, Hox/HOM genes have been identified in organisms as distantly related as arthropods, vertebrates, nematodes, and cnidarians. Data obtained in parallel from the organization of the complex, the domains of gene expression during embryogenesis, and phylogenetic relationships allow the subdivision of the Hox/HOM superclass into five classes (lab, pb/Hox3, Dfd, Antp, and Abd-B) that appeared early during metazoan evolution. We describe a search for homologues of these genes in platyhelminths, triploblast metazoans emerging as an outgroup to the great coelomate ensemble. A degenerate PCR screening for Hox/HOM homeoboxes in three species of triclad planarians has revealed 10 types of Antennapedia-like genes. The homeobox-containing sequences of these PCR fragments allowed the amplification of the homeobox-coding exons for five of these genes in the species Polycelis nigra. A phylogenetic analysis shows that two genes are clear orthologues of Drosophila labial, four others are members of a Dfd/Antp superclass, and a seventh gene, although more difficult to classify with certainty, may be related to the pb/Hox3 class. Together with previously identified Hox/HOM genes in other flatworms, our analyses demonstrate the existence of an elaborate family of Hox/HOM genes in the ancestor of all triploblast animals.
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