ArticleProceedings of the National Academy of Sciences of the United States of America1995
Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 176 citations in OpenAlex.
- Immunomodulatory effect of NSAID in geriatric patients with acute infection: effects of piroxicam on chemokine/cytokine secretion patterns and levels of heat shock proteins. A double-blind randomized controlled trial. (ISRCTN58517443).Cell stress & chaperones · 2012Trial
- Expression of circulating GRP78 and gp96, endoplasmic reticulum stress-related proteins, in menstrual and bladder pain sensitivity.Scientific reports · 2026Article
- Introducing Molecular Chaperones into the Causality and Prospective Management of Autoimmune Hepatitis.Digestive diseases and sciences · 2023Review
- Quantitative Comparison of HSF1 Activators.Molecular biotechnology · 2022Article
- Article
- Transgenic crops for the agricultural improvement in Pakistan: a perspective of environmental stresses and the current status of genetically modified crops.GM crops & food · 2020Review
- Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA.Molecular and cellular biology · 2018Article
- Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans.Cell stress & chaperones · 2018Article
- The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells.Journal of veterinary science · 2016Article
- Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.Cell stress & chaperones · 2015Article
- Article
- Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.The Journal of biological chemistry · 2012Article
- Protein homeostasis as a therapeutic target for diseases of protein conformation.Current topics in medicinal chemistry · 2012Review
- Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.Nature reviews. Drug discovery · 2011Review
- Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.PloS one · 2011Article
- Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.Prostaglandins & other lipid mediators · 2010Article
- Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.PLoS biology · 2010Article
- Protein homeostasis in models of aging and age-related conformational disease.Advances in experimental medicine and biology · 2010Review
- Cellular stress-response modulators in the acute rat model of peritoneal dialysis.Pediatric nephrology (Berlin, Germany) · 2010Article
- Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.Genes & development · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The activation of heat shock genes by diverse forms of environmental and physiological stress has been implicated in a number of human diseases, including ischemic damage, reperfusion injury, infection, neurodegeneration, and inflammation. The enhanced levels of heat shock proteins and molecular chaperones have broad cytoprotective effects against acute lethal exposures to stress. Here, we show that the potent antiinflammatory drug indomethacin activates the DNA-binding activity of human heat shock transcription factor 1 (HSF1). Perhaps relevant to its pharmacological use, indomethacin pretreatment lowers the temperature threshold of HSF1 activation, such that a complete heat shock response can be attained at temperatures that are by themselves insufficient. The synergistic effect of indomethacin and elevated temperature is biologically relevant and results in the protection of cells against exposure to cytotoxic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.