ArticleProceedings of the National Academy of Sciences of the United States of America1995
Tissue specificity of a glucocorticoid-dependent enhancer in transgenic mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 22 citations in OpenAlex.
- The role of glucocorticoids and corticotropin-releasing hormone regulation on anxiety symptoms and response to treatment.Endocrine connections · 2017Review
- Glucocorticoid-induced DNA demethylation and gene memory during development.The EMBO journal · 2001Article
- Antiglucocorticoid activity of hepatocyte nuclear factor-6.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Glucocorticoids are insufficient for neonatal gene induction in the liver.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The human pH aldolase A promoter directs widespread but muscle-predominant expression in transgenic mice.Transgenic research · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glucocorticoid-responsive units (GRUs) of the rat tyrosine aminotransferase were associated with the regulatory sequences of a cellular gene expressed ubiquitously--that coding for the largest subunit of RNA polymerase II. In transient expression assays, glucocorticoid responsiveness of the hybrid regulatory regions depends on the spatial relationship and number of regulatory elements. Two parameters affect the ratio of induction by glucocorticoids: the basal level of the hybrid promoter that is affected by the RNA polymerase II regulatory sequences and the glucocorticoid-induced level that depends on the distance between the GRUs and the TATA box. A fully active glucocorticoid-responsive hybrid gene was used to generate transgenic mice. Results show that a composite regulatory pattern is obtained: ubiquitous basal expression characteristic of the RNA polymerase II gene and liver-specific glucocorticoid activation characteristic of the tyrosine aminotransferase GRUs. This result demonstrates that the activity of the tyrosine aminotransferase GRUs is cell-type-specific not only in cultured cells but also in the whole animal.
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Registered trials
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