ArticleProceedings of the National Academy of Sciences of the United States of America1995
Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 99 citations in OpenAlex.
- Nitration in cancer signaling.Redox biology · 2026Review
- ECPUB5 Polyubiquitin Gene inGenes · 2024Article
- Structure of the transcribing RNA polymerase II-Elongin complex.Nature structural & molecular biology · 2023Article
- Elongin B is a binding partner of the male germ cell nuclear speckle protein sperm-associated antigen 16S (SPAG16S) and is regulated post-transcriptionally in the testis.Reproduction, fertility, and development · 2019Article
- Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.The Journal of biological chemistry · 2017Article
- The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions.Cell division · 2016Review
- Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.The Journal of biological chemistry · 2015Article
- Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.Retrovirology · 2013Article
- Article
- Integrated molecular analysis of clear-cell renal cell carcinoma.Nature genetics · 2013Article
- Interleukin-6: a multifunctional targetable cytokine in human prostate cancer.Molecular and cellular endocrinology · 2012Review
- The Role of Elongin BC-Containing Ubiquitin Ligases.Frontiers in oncology · 2012Article
- Article
- Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.The EMBO journal · 2008Article
- VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.Genes & development · 2004Article
- In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development.Molecular and cellular biology · 2004Article
- Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Journal of virology · 2002Article
- Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein.The Journal of clinical investigation · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
General transcription factor SIII, a heterotrimer composed of 110-kDa (p110), 18-kDa (p18), and 15-kDa (p15) subunits, increases the catalytic rate of transcribing RNA polymerase II by suppressing transient pausing by polymerase at multiple sites on DNA templates. Here we report molecular cloning and biochemical characterization of the SIII p18 subunit, which is found to be a member of the ubiquitin homology (UbH) gene family and functions as a positive regulatory subunit of SIII. p18 is a 118-amino acid protein composed of an 84-residue N-terminal UbH domain fused to a 34-residue C-terminal tail. Mechanistic studies indicate that p18 activates SIII transcriptional activity above a basal level inherent in the SIII p110 and p15 subunits. Taken together, these findings establish a role for p18 in regulating the activity of the RNA polymerase II elongation complex, and they bring to light a function for a UbH domain protein in transcriptional regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.