ArticleJournal of virology1995
In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Molecular Mechanisms and Animal Models of HBV-Related Hepatocellular Carcinoma: With Emphasis on Metastatic Tumor Antigen 1.International journal of molecular sciences · 2021Review
- Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein.Laboratory animal research · 2020Review
- In Vivo Model Systems for Hepatitis B Virus Research.ACS infectious diseases · 2019Review
- Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Hepatitis B Virus X and Regulation of Viral Gene Expression.Cold Spring Harbor perspectives in medicine · 2016Review
- Involvement of DNA damage response pathways in hepatocellular carcinoma.BioMed research international · 2014Review
- Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection.Clinical and vaccine immunology : CVI · 2011Article
- Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis.Oncogene · 2004Article
- Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver.Oncogene · 2002Article
- Hepatocarcinogenesis in hepatitis viral infection: lessons from transgenic mouse studies.Journal of gastroenterology · 2002Review
- Hepatitis B virus and hepatocellular carcinoma.International journal of experimental pathology · 2001Review
- Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions.Journal of virology · 2001Article
- Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis.Oncogene · 2001Article
- Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice.Journal of virology · 2000Article
- The hepatitis B virus X protein transactivates viral core gene expression in vivo.Journal of virology · 1999Article
- Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene.World journal of gastroenterology · 1998Article
- Hepatitis B virus X protein interferes with cellular DNA repair.Journal of virology · 1998Article
- Promoters for synthesis of the pre-C and pregenomic mRNAs of human hepatitis B virus are genetically distinct and differentially regulated.Journal of virology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of the hepatitis B virus enhancers I and II in the regulation of the activity of the core and the X promoters was assessed in transgenic mice. Surprisingly, despite the presence of heterologous promoters linked 5' of the X gene, the transgene expression is mostly due to core promoter (Cp) activity present in the X coding sequence. Moreover, the restriction of Cp activity to hepatic tissue required the combined action of both enhancers I and II, whereas the proximity of these two enhancers was insufficient to confer tissue specificity on Xp activity. Furthermore, the liver-specific activity of the Cp was developmentally regulated in an enhancer I-independent manner.
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