ArticleJournal of virology1995
Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Immune responses of the domestic fowl to Dermanyssus gallinae under laboratory conditions.Parasitology research · 2010Article
- Regulation of proinflammatory cytokine expression in primary mouse astrocytes by coronavirus infection.Journal of virology · 2009Article
- Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling.Viral immunology · 2008Article
- Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair.Frontiers in bioscience : a journal and virtual library · 2008Article
- Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.Journal of virology · 2008Article
- CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.Journal of virology · 2008Article
- Coronavirus infection of the central nervous system: host-virus stand-off.Nature reviews. Microbiology · 2006Review
- Differential induction of proinflammatory cytokines in primary mouse astrocytes and microglia by coronavirus infection.Advances in experimental medicine and biology · 2006Article
- Coronavirus immunity: from T cells to B cells.Advances in experimental medicine and biology · 2006Review
- Effect of asymptomatic natural infections due to common mouse pathogens on the metastatic progression of B16 murine melanoma in C57BL/6 mice.Clinical & experimental metastasis · 2005Article
- Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells.Journal of virology · 2004Article
- Virus demyelination.Journal of neurovirology · 2003Review
- CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus.Journal of virology · 2002Article
- Murine hepatitis virus--a model for virus-induced CNS demyelination.Journal of neurovirology · 2002Review
- Mouse hepatitis virus.Current opinion in microbiology · 2001Review
- B-cell-mediated lysis of cells infected with the neurotropic JHM strain of mouse hepatitis virus.Virology · 2001Article
- Viral induced demyelination.Brain pathology (Zurich, Switzerland) · 2001Review
- Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase.Journal of virology · 2000Article
- Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus.Journal of virology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Neutralizing anti-tumor necrosis factor alpha (TNF-alpha) antibody treatment of mice infected with the neurotropic JHMV strain of mouse hepatitis virus showed no reduction of either virus-induced encephalomyelitis or central nervous system demyelination. TNF-alpha-positive cells were present in the central nervous system during infection; however, TNF-alpha could not be colocalized with JHMV-infected cells. In vitro, TNF-alpha mRNA rapidly accumulated following JHMV infection; however, no TNF-alpha was secreted because of inhibition of translation. Both live and UV-inactivated virus inhibited TNF-alpha secretion induced by lipopolysaccharide. These data show that TNF-alpha is not secreted from infected cells and indicate that if contributes to either JHMV-induced acute encephalomyelitis nor primary demyelination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.