Evidence map›Paper›PMID 7637010›Full record

ArticleJournal of virology1995

Variability of human immunodeficiency virus type 1 group O strains isolated from Cameroonian patients living in France.

I Loussert-Ajaka, M L Chaix, B Korber, F Letourneur, E Gomas, E Allen, T D Ly, F Brun-Vézinet, F Simon, S Saragosti

Abstract readComparative Study
In one paragraph

Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  6. Genetic correlates influencing immunopathogenesis of HIV infection.The Indian journal of medical research · 2011
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

I Loussert-AjakaLaboratoire de Virologie, Hôpital Bichat-Claude Bernard, Paris, France.
M L Chaix
B Korber
F Letourneur
E Gomas
E Allen
T D Ly
F Brun-Vézinet
F Simon
S Saragosti

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1) nucleotide sequences encoding p24Gag and the Env C2V3 region were obtained from seven patients who were selected on the basis of having paradoxical seronegativity on a subset of HIV enzyme-linked immunosorbent assay detection kits and having atypical Western blot (immunoblot) reactivity. Sequence analyses showed that all of these strains were more closely related to the recently described Cameroonian HIV isolates of group O (HIV-1 outlier) than to group M (HIV-1 major). All seven patients had Cameroonian origins but were living in France at the time the blood samples were taken. Characterization of a large number of group M strains has to date revealed eight distinct genetic subtypes (A to H). Genetic distances between sequences from available group O isolates were generally comparable to those observed in M intersubtype sequence comparisons, showing that the group O viruses are genetically very diverse. Analysis of sequences from these seven new viral strains, combined with the three previously characterized group O strains, revealed few discernable phylogenetic clustering patterns among the 10 patients' viral sequences. The level of diversity among group O sequences suggests that they may have a comparable (or greater) age than the M group sequences, although for unknown reasons, the latter group dispersed first and is the dominant lineage in the pandemic.

Indexed as

Genetic VariationPhylogenyAcquired Immunodeficiency SyndromeAdultAgedAmino Acid SequenceBase SequenceBlotting, WesternCameroonCloning, MolecularDNA PrimersDNA, ViralEnzyme-Linked Immunosorbent AssayFemaleFranceGene Products, envDNA PrimersDNA, ViralGene Products, envGene Products, gag

Identifiers

PMID7637010
PMCPMC189421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.