ArticleJournal of virology1995
Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.
Article in Journal of virology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 71 citations in OpenAlex.
- The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities.International journal of molecular sciences · 2023Review
- Novel Regulators of the IGF System in Cancer.Biomolecules · 2021Review
- MicroRNA-497 regulates cell proliferation in hepatocellular carcinoma.Oncology letters · 2016Article
- The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma.Molecular cancer · 2015Article
- MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor.Oncogene · 2013Article
- The insulin and igf-I pathway in endocrine glands carcinogenesis.Journal of oncology · 2012Article
- Gene expression analysis of pancreatic cystic neoplasm in SV40Tag transgenic mice model.World journal of gastroenterology · 2007Article
- Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells.Molecular and cellular biology · 2004Article
- A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer.Clinical & experimental metastasis · 2004Article
- Article
- Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.Oncogene · 2001Article
- IGF-I receptor signalling in transformation and differentiation.Molecular pathology : MP · 2001Review
- Review
- Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.Molecular and cellular biology · 1998Article
- Insulin-like growth factor I receptor signaling in transformation by src oncogenes.Molecular and cellular biology · 1997Article
- Insulin-like growth factor II stimulates cell proliferation through the insulin receptor.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mouse embryo cells with a targeted disruption of the insulin-like growth factor I receptor (IGF-IR) genes (R- cells) are refractory to transformation by the simian virus 40 large T antigen and/or an activated and overexpressed Ras, both of which readily transform cells from wild-type littermate embryos and other 3T3-like cells. R- cells are also refractory to transformation induced by overexpressed epidermal growth factor receptor and platelet-derived growth factor receptor beta. Since the platelet-derived growth factor receptor beta is required for transformation by bovine papillomavirus, we inquired whether the IGF-IR was also required for transformation by bovine papillomavirus E5 oncoprotein. We show here that R- cells are refractory to transformation by E5; reintroduction into R- cells of a human IGF-IR restores the susceptibility to transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.