ArticleThe Journal of clinical investigation1995
Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 67 citations in OpenAlex.
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- Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations.Molecular neurobiology · 2025Article
- Induction of Oxidative Stress and Alteration of Synaptic Gene Expression in Newborn Hippocampal Granule Cells after Developmental Exposure to Aroclor 1254.Neuroendocrinology · 2023Article
- The Effects of Early-Life Iron Deficiency on Brain Energy Metabolism.Neuroscience insights · 2020Review
- Maternal hormonal milieu influence on fetal brain development.Brain and behavior · 2018Review
- Maternal iron supplementation attenuates the impact of perinatal copper deficiency but does not eliminate hypotriiodothyroninemia nor impaired sensorimotor development.The Journal of nutritional biochemistry · 2011Article
- Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone concentrations.Endocrinology · 2010Article
- Thyroid hormone and cerebellar development.Cerebellum (London, England) · 2008Review
- Functional analysis of basic transcription element binding protein by gene targeting technology.Molecular and cellular biology · 2003Article
- Action of thyroid hormone in brain.Journal of endocrinological investigation · 2002Review
- Regulation of mitochondrial biogenesis in brown adipose tissue: nuclear respiratory factor-2/GA-binding protein is responsible for the transcriptional regulation of the gene for the mitochondrial ATP synthase beta subunit.The Biochemical journal · 1998Article
- Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism.The Journal of clinical investigation · 1997Article
- Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat.The Biochemical journal · 1997Article
- Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation.The EMBO journal · 1996Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone (T3) plays a critical role in the development of the central nervous system and its deficiency during the early neonatal period results in severe brain damage. However the mechanisms involved and the genes specifically regulated by T3 during brain development are largely unknown. By using a subtractive hybridization technique we have isolated a number of cDNAs that represented mitochondrial genes (12S and 16S rRNAs and cytochrome c oxidase subunit III). The steady state level of all three RNAs was reduced in hypothyroid animals during the postnatal period and T3 administration restored control levels. During fetal life the level of 16S rRNA was decreased in the brain of hypothyroid animals, suggesting a prenatal effect of thyroid hormone on brain development. Since T3 does not affect the amount of mitochondrial DNA, the results suggest that the effect of T3 is at transcriptional and/or postranscriptional level. In addition, the transcript levels for two nuclear-encoded mitochondrial cytochrome c oxidase subunits: subunits IV and VIc were also decreased in the brains of hypothyroid animals. Hypothyroidism-induced changes in mitochondrial RNAs were followed by a concomitant 40% decrease in cytochrome c oxidase activity. This study shows that T3 is an important regulator of mitochondrial function in the neonatal brain and, more importantly, provides a molecular basis for the specific action of this hormone in the developing brain.
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