ArticleThe Journal of clinical investigation1995
Role of interleukin-1 in the pathogenesis of experimental shigellosis.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 132 citations in OpenAlex.
- O-specific [corrected] polysaccharide conjugate vaccine-induced [corrected] antibodies prevent invasion of Shigella into Caco-2 cells and may be curative.Proceedings of the National Academy of Sciences of the United States of America · 2007Trial
- Sequential invasion of epithelial and immune cells in Shigellosis.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mitochondrion-Dependent Apoptosis Is Essential for Rickettsia parkeri Infection and Replication in Vector Cells.mSystems · 2021Article
- Mechanisms of bacillary dysentery: lessons learnt from infant rabbits.Gut microbes · 2020Review
- Human Enteric Defensin 5 PromotesInfection and immunity · 2019Article
- Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery.Nature communications · 2019Article
- Review
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Subversion of inflammasome activation and pyroptosis by pathogenic bacteria.Frontiers in cellular and infection microbiology · 2013Review
- Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis.Infection and immunity · 2011Article
- The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding.Infection and immunity · 2010Article
- Enteric infections, diarrhea, and their impact on function and development.The Journal of clinical investigation · 2008Review
- Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.Clinical microbiology reviews · 2008Review
- ShiA abrogates the innate T-cell response to Shigella flexneri infection.Infection and immunity · 2006Article
- Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants.Infection and immunity · 2003Article
- Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus.Infection and immunity · 2003Article
- Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production.Infection and immunity · 2002Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of human recombinant interleukin-1 receptor antagonist on intestinal inflammation, tissue destruction, and bacterial invasion during experimental shigellosis caused by Shigella flexneri was studied in the rabbit-ligated loop infection model. Intravenous infusion of the inhibitor at a dose of 2 mg/kg per h, was initiated 30 min before intestinal loops were ligated and infected, and continued during the 8-h period of infection. The animals treated with IL-1 receptor antagonist showed a striking decrease in inflammation, destruction, and bacterial invasion of their tissues, both at the level of the villous intestine and Peyer's patches. This is conclusive evidence that interleukin-1 plays a critical role in the pathogenesis of shigellosis. This proinflammatory cytokine is here proposed as a major trigger of the inflammatory reaction which is characteristic of this invasive disease of the intestine, due to the particular interaction existing between S. flexneri and macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.