ArticleThe Journal of clinical investigation1995
Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 114 citations in OpenAlex.
- Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats.Frontiers in physiology · 2022Article
- Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats.Journal of cellular and molecular medicine · 2019Article
- Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction.Scientific reports · 2017Article
- Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?Circulation research · 2016Article
- Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction.Experimental and therapeutic medicine · 2016Article
- Cardiac remodeling and physical training post myocardial infarction.World journal of cardiology · 2015Review
- Exercise training in adverse cardiac remodeling.Pflugers Archiv : European journal of physiology · 2014Review
- Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats.Clinics (Sao Paulo, Brazil) · 2013Article
- Administration of pigment epithelium-derived factor inhibits left ventricular remodeling and improves cardiac function in rats with acute myocardial infarction.The American journal of pathology · 2011Article
- Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats.Clinics (Sao Paulo, Brazil) · 2011Article
- Effects of exercise and L-arginine on ventricular remodeling and oxidative stress.Medicine and science in sports and exercise · 2010Article
- Effects of exercise training on cardiac function and myocardial remodeling in post myocardial infarction rats.Journal of molecular and cellular cardiology · 2008Article
- Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart.Molecular and cellular biochemistry · 2007Article
- The CRM1 nuclear export receptor controls pathological cardiac gene expression.Molecular and cellular biology · 2004Article
- Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart.Molecular and cellular biochemistry · 2003Article
- Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction.The Journal of physiology · 1999Article
- Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice.The Journal of clinical investigation · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continued adverse remodeling of myocardium after infarction may lead to progressive ventricular dilation and heart failure. We tested the hypothesis that exercise training in a healed myocardial infarction-dysfunction rat model can favorably modify the adverse effects of ventricular remodeling including attenuation of abnormal myosin gene expression. Sprague-Dawley rats were subjected to either proximal LAD ligation or sham operation. At 5 wk after the operation, animals were randomly assigned to sedentary conditions or 6 wk of graduated swim training, creating four experimental groups: infarct sedentary (IS), infarct exercise (IE), sham sedentary (SS), and sham exercise (SE). At 11 wk all rats were sacrificed and analyzed. Compared to sedentary infarct controls, exercise training attenuated left ventricular (LV) dilation and allowed more hypertrophy of the non infarct wall. The exercise-trained hearts also showed a reduction in the estimated peak wall tension. Northern blot analysis showed an increase in beta-myosin heavy chain expression in the hearts of the sedentary infarction group soon after infarction when compared to sham controls. However, with exercise training, there was a significant attenuation of the beta-myosin heavy chain expression in the myocardium. Exercise training in a model of left ventricular dysfunction after healed myocardial infarction can improve the adverse remodeling process by attenuating ventricular dilation and reducing wall tension. The abnormal beta-myosin expression was also attenuated in the exercise trained group. This is evidence that abnormal gene expression following severe myocardial infarction dysfunction can be favorably modified by an intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.