ArticleThe Journal of clinical investigation1995
Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.
Article in The Journal of clinical investigation, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 71 citations in OpenAlex.
- Identifying Key Genes and Functionally Enriched Pathways in Osteoporotic Patients by Weighted Gene Co-Expression Network Analysis.Biochemical genetics · 2024Article
- The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding.Scientific reports · 2017Article
- Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine.Immunology · 2012Article
- Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model.The Journal of clinical investigation · 2012Article
- The porcine antibody repertoire: variations on the textbook theme.Frontiers in immunology · 2012Article
- Impaired early B cell tolerance in patients with rheumatoid arthritis.The Journal of experimental medicine · 2005Article
- Age-related accumulation of Ig V(H) gene somatic mutations in peripheral B cells from aged humans.Clinical and experimental immunology · 2003Article
- B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response.Arthritis research · 2002Article
- Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes.Arthritis research · 2002Review
- Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein.The American journal of pathology · 2001Article
- Impact of age on hypermutation of immunoglobulin variable genes in humans.Journal of clinical immunology · 2001Article
- The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform.The Journal of experimental medicine · 2001Article
- Production and characterization of monoclonal IgM autoantibodies specific for the T-cell receptor.Journal of protein chemistry · 2000Article
- IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process.Arthritis research · 2000Article
- Detection of immunoglobulin kappa light chain rearrangements by polymerase chain reaction. An improved method for detecting clonal B-cell lymphoproliferative disorders.The American journal of pathology · 1999Article
- Age-related alterations of somatic hypermutation and CDR3 lengths in human Vkappa4-expressing B lymphocytes.Immunology · 1999Article
- A human immunoglobulin lambda locus is similarly well expressed in mice and humans.The Journal of experimental medicine · 1999Article
- Frequent N addition and clonal relatedness among immunoglobulin lambda light chains expressed in rheumatoid arthritis synovia and PBL, and the influence of V lambda gene segment utilization on CDR3 length.Molecular medicine (Cambridge, Mass.) · 1998Article
- Differential use of immunoglobulin light chain genes and B lymphocyte expansion at sites of disease in rheumatoid arthritis (RA) compared with circulating B lymphocytes.Clinical and experimental immunology · 1998Article
- VH usage and somatic hypermutation in peripheral blood B cells of patients with rheumatoid arthritis (RA).Clinical and experimental immunology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Immunoglobulin secretion by plasma cells infiltrating synovial membranes is a prominent feature of RA. Previous analyses of a cDNA library generated from synovium of RA patient BC revealed immunoglobulin kappa light chain transcripts with extensive somatic mutation, frequent N region addition, and unexpected variation in the lengths of CDR3 regions which form the center of the antigen binding site. To determine if these characteristics are present in other individuals, we performed reverse transcription-polymerase chain reaction amplification and sequenced > or = 10 V kappa-containing amplicons from nine tissue samples: synovia of three individuals with long-standing RA (including patient BC), PBLs of two of these individuals, and PBLs or splenocytes of four normal individuals. Increased levels of somatic mutation in PBLs appeared to correlate with increased age, which may reflect accumulation of circulating memory cells and/or decreased bone marrow production of naive B lymphocytes. Two of three RA synovial samples and both RA PBL samples exhibited increased proportions of clones with unusual CDR3 lengths. Enrichment for these antibody binding sites could be due to abnormal regulation of the emerging repertoire or to selection for B lymphocytes bearing antibodies of unusual specificity, and may play a role in the pathogenesis of RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.